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Formulated by a medical doctor
No prescription needed
Safe & natural ingredients

Discover the freedom and confidence when you leave behind gas, bloating & constipation

 
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How can this new doctor-formulated Viscera-3 breakthrough solve such a big problem so quickly?

Simple: It all starts with the gut-healing power of POST-Biotics... What are they?

Corebiome
POST-Biotic Technology Rapidly Relieves Bloating, Gas & Constipation
Medical-Grade
Tributyrin: Corebiome® (550mg)

  • Swiftly Reduces Gas and Bloating With Powerful POST-Biotic Technology: By balancing the gut microbiome up to 11-times better than PRO-Biotics, POST-Biotics help reduce the causes of bathroom issues, gas, and bloating.1

  • Lighting-Fast Constipation Relief: POST-Biotics enhance gut motility and bowel regularity by providing energy for colon cells. Research indicates that it increases stool frequency and softens stools, aiding in improved regularity.2

  • Potent Tool For Long-Term Gut Health: POST-Biotics strengthen the gut lining and lower gut inflammation, boosting nutrient absorption and easing bloating. They provide superior disease defense by enhancing gut barrier function and overall digestive health.3

White powder
Nature’s Fast, Safe, and Gentle Stool Softener & Bloat Reliever
Medical-Grade
Magnesium Blend + Oxide & Glycinate (110mg)

  • Quickly Reduces Constipation: Magnesium oxide is commonly used as a gentle laxative to swiftly alleviate constipation. It works by drawing water into the intestines, making it easier to pass.4

  • Rapidly Alleviates Gas and Bloating: Magnesium helps to relax the intestinal muscles, which can reduce the pain associated with gas and bloating. It ensures gas moves smoothly through the digestive tract, preventing painful bloating.5

  • Supports Overall Digestive Health: Beyond its effects on constipation and bloating, it plays a pivotal role in overall digestive enzyme production, helping the body quickly break down food and absorb nutrients.6

Grapes
Soothe The Belly, Fight Leaky Gut, And Reduce Inflammation
Medical-Grade
Grape Seed Extract (95% Proanthocyanidins)

  • Soothes Gastrointestinal Inflammation: The anti-inflammatory properties of grape seed extract have been shown effective against gastrointestinal conditions, helping to reduce gut inflammation and associated symptoms such as bloating and constipation.7

  • Enhances Intestinal Barrier Function: Grape seed extract swiftly strengthens the intestinal barrier, which is crucial for preventing disorders like leaky gut syndrome. Its proanthocyanidins can help reduce inflammation and improve the gut lining's integrity.8

  • Balances Gut Microbiota: Grape seed extract quickly promotes the growth of beneficial gut bacteria, enhancing digestive health and supporting immune function. Its polyphenols act like prebiotics, supporting a healthier gut flora balance.9

Pomegranate
Gut-Protective Belly-Soothing Catalysts
Medical-Grade
Synergistic Medical-Grade Nutrients That Super-Charge The Formula

  • Reduce Waist Size & Fight Gut Inflammation With Pomegranate Extract(40% Ellagic acids): Pomegranate is known as the miracle “forever fruit”. Recent studies have also revealed it as a powerful anti-aging gut health secret with potent anti-inflammatory properties, especially in the gut10. Research shows that it may help curb appetite and reduce body fat. 11

  • Chromium Picolinate To Feel Fuller and Reduce Appetite: Chromium is an essential mineral that can help in maintaining gut health and shrinking the belly. Chromium picolinate can make you feel more full and reduce cravings and appetite.12

How can this new doctor-formulated breakthrough solve such a big problem so quickly?

Simple: It all starts with the gut-healing power of POST-Biotics... What are they?

Corebiome
POST-Biotic Breakthrough Rapidly Relieves Bloating, Gas & Constipation
Medical-Grade
Tributyrin: Corebiome® (550mg)

  • • Swiftly Reduces Gas and Bloating With Powerful POST-Biotic Technology: By balancing the gut microbiome up to 11-times better than PRO-Biotics, POST-Biotics help reduce the causes of bathroom issues, gas, and bloating.1

  • Lighting-Fast Constipation Relief: POST-Biotics enhance gut motility and bowel regularity by providing energy for colon cells. Research indicates that it increases stool frequency and softens stools, aiding in improved regularity.2

  • Potent Tool For Long-Term Gut Health: POST-Biotics strengthen the gut lining and lower gut inflammation, boosting nutrient absorption and easing bloating. They provide superior disease defense by enhancing gut barrier function and overall digestive health.3

White powder
Nature’s Fast, Safe, and Gentle Stool Softener & Bloat Reliever
Medical-Grade
Magnesium Blend + Oxide & Glycinate (110mg)

  • Quickly Reduces Constipation: Magnesium oxide is commonly used as a gentle laxative to swiftly alleviate constipation. It works by drawing water into the intestines, making it easier to pass.4

  • Rapidly Alleviates Gas and Bloating: Magnesium helps to relax the intestinal muscles, which can reduce the pain associated with gas and bloating. It ensures gas moves smoothly through the digestive tract, preventing painful bloating.5

  • Supports Overall Digestive Health: Beyond its effects on constipation and bloating, it plays a pivotal role in overall digestive enzyme production, helping the body quickly break down food and absorb nutrients.6

Grapes
Soothe The Belly, Fight Leaky Gut, And Reduce Inflammation
Medical-Grade
Grape Seed Extract (95% Proanthocyanidins)

  • Soothes Gastrointestinal Inflammation: The anti-inflammatory properties of grape seed extract are have been shown effective against gastrointestinal conditions, helping to reduce gut inflammation and associated symptoms such as bloating and constipation.7

  • Enhances Intestinal Barrier Function: Grape seed extract swiftly strengthens the intestinal barrier, which is crucial for preventing disorders like leaky gut syndrome. Its proanthocyanidins can help reduce inflammation and improve the gut lining's integrity.8

  • Balances Gut Microbiota: Grape seed extract quickly promotes the growth of beneficial gut bacteria, enhancing digestive health and supporting immune function. Its polyphenols act like prebiotics, supporting a healthier gut flora balance.9

Pomegranate
Gut-Protective Belly-Soothing Catalysts
Medical-Grade
Synergistic Medical-Grade Nutrients That Super-Charge The Formula

  • Reduce Waist Size & Fight Gut Inflammation With Pomegranate Extract(40% Ellagic acids): Pomegranate is known as the miracle “forever fruit”. Recent studies have also revealed it as a powerful anti-aging gut health secret with potent anti-inflammatory properties, especially in the gut10. Research shows that it may help curb appetite and reduce body fat. 11

  • Chromium Picolinate To Feel Fuller and Reduce Appetite: Chromium is an essential mineral that can help in maintaining gut health and shrinking the belly. Chromium picolinate can make you feel more full and reduce cravings and appetite.12

Quickly Fix Bathroom & Digestive Issues With Medical-Grade Viscera-3

Slim Down Your Belly In As Little As 3 Days

By reducing bloating and flipping on your “slim gut switch” you can eliminate up to 17lbs of gut muck and rapidly shrink your belly.

Reduce Embarrassing Gas Fast

Decrease embarrassing gas production, minimize gas pain, and support a healthier digestive process.

End The Frustration of Constipation

Promotes a return to "regular" gut health, helping you enjoy life without painful and toxic constipation.

Stop Painful Bloating Quickly

Soothe your gut and reduce uncomfortable bloating for more comfortable, energy-filled days and restful nights.

Protect From Deadly "Gut Diseases"

Contains powerful POST-Biotics that protect against potentially toxic and dangerous gut imbalances that can lead to disease.

Dramatically Increase Energy

Poor gut health slows you down. Enjoy better sleep and more energetic mornings. Feel light and filled with energy today!

“Viscera-3® is the most effective supplement for bathroom issues and gut health I’ve ever seen or used. Its patented POST-biotic technology targets the lower color leading to rapid results you can see in your toilet and mirror.”

Dr. Matthew Olesiak M.D., Ivy League Trained Doctor

Clinical and real-world results you can trust

Powerful results from clinical studies and real-world users:
  • Independent, 3rd-party studies
  • Randomized controlled trials
  • Published in the Journal of Gastroenterology Review

Pituch A, Walkowiak J, Banaszkiewicz A. Butyric acid in functional constipation. Journal of Gastroenterology Review. 2013;8(5):295-298. doi:10.5114/pg.2013.38731.

76%
Got Bathroom Relief Within 3 Days
82%
Noticed A Slimmer Belly Within A Week
88%
Got Better Results Than With Fiber or Probiotic Supplements

Shared stories, shared relief.

Safe and Effective Bloating, Constipation & Digestive Relief

No Harmful Side Effects, Just Gentle Relief

Viscera-3 is all-natural, avoiding the side effects common with prescription medications. It’s safe for ongoing use, allowing you to manage digestive health without worrying about harmful long-term effects.

Quickly Targets the Root Problem and Is Safe for Long-Term Use

Unlike temporary solutions that may have severe side effects, Viscera-3 offers lasting relief and is gentle on your body. It targets the root cause of digestive issues with natural ingredients backed by science.

Uses Only the Highest-Quality, 100% Safe Ingredients

As all of our families use Viscera-3, we commit to pharmaceutical-grade, non-GMO ingredients. We adhere to GMP standards and conduct purity testing throughout the manufacturing process to support your digestive health and peace of mind.

SANE:MD Viscera-3 Pill

SANE:MD Viscera-3®

Targets the root cause of stuck gut muck, bathroom and gut problems

Scientifically validated natural ingredients

No side effects ever

Lasting results in as little as 3 days!

Conventional Medication Pill

Conventional Medications

Only Masks the Symptoms

Temporary Solution

Associated with significant side effects

Negative effects on your entire body

You are not alone. Feel the support
from our community...

All your questions answered

How many bottles should I order?

Less bloating and digestive upsets within 48 hours of using Viscera-3® daily? YES PLEASE! Once you start, you’ll never want to stop, and results improve the longer Viscera-3® is taken. Do yourself a favor and order the 6-bottle bundle. Trust me. Plus, if you’re like me and you love a good bargain, the 6-bottle bundle saves you the most money (50% off the regular price with the limited-time discount!)

Remember, Viscera-3® contains the highest-grade nutrients and the patented, superior form of TRIButyrate, and we produce it in small batches for maximum freshness and effectiveness. They sell out often, so stock up today, save money, and be sure you don't run out of your new SLIM gut secret advantage!

Of course, if you decide the product is not for you can always return the unused portion for a refund (we offer a 1-year satisfaction guarantee** so you’re always safe).

What if I get it and it's just not for me?

You’re going to love Viscera-3®, but even if you don’t, you’re covered! Every customer is protected by a full ONE-YEAR; no questions asked, FULL MONEY BACK GUARANTEE.** You can feel confident taking advantage of the HUGE savings when you order multiple bottles today.

What are the nutrients and amounts in SANE Viscera-3®?

Have a look for yourself:

Viscera-3 suppliment label

Where is it manufactured?

Viscera-3® is proudly manufactured, packed, and shipped in the USA.

Is it non-GMO and gluten-free?

Yes! None of our products contain GMO foods or gluten.

How long will it take before I start to feel the benefits?

In my personal experience, and my family’s, while some people have reported significant benefits in just days, everyone I’ve talked to said they felt life-changing benefits in about 30 days.

For some people, the benefits may not appear gradually but rather all at once (aka suddenly) once the active ingredients in Viscera-3® have reached the levels necessary to effect change.

How many should I take each day?

This varies greatly from person to person and the results you wish to achieve. However, to begin we recommend taking 2 capsules per day, right after you wake up and brush your teeth.

What is the best time of day to take Viscera-3®?

To help this new SLIM gut habit take hold, we recommend that you do it every morning after you brush your teeth.

Who is Viscera‑3® for?

That is a great question.

Viscera‑3® is a natural remedy for anyone who wants to end their constipation and other digestive issues, improve overall health, restore youthful vigor, and help with losing that stubborn fat.

It works for men and women of all ages, regardless of their diet or how many things they have tried before.

It does this by rebalancing gut bacteria and increasing levels of Butyrate, which helps overcome Embedded Food Syndrome (EFS), the root cause of your constipation, and other gut health issues.

This is the only formulation of its kind proven to work for millions of people.

What makes Viscera‑3® different from other products I’ve tried?

No other supplement out there contains the multi-part formulation in Viscera‑3®.

Patented TRIButyrate and the 4 other nutrients in this multifactor formula have been widely studied and shown to provide dozens of incredible health benefits, many of which I detailed earlier.

These nutrients overcome Embedded Food Syndrome, a condition that few doctors know about.

As Viscera‑3® helps ends your blockage, it also ends your gas, bloating, and constipation. Plus, it helps you lose weight and slim your belly.

The ingredients in Viscera‑3® are backed by rigorous testing and clinical studies proving their effectiveness.

Viscera‑3® is guaranteed to work for you. It doesn’t matter if 50 other products failed to fix your constipation and other slim gut health issues.

But it might help to know the reason these other products failed…

You see, those other products did NOT work because they weren’t designed to clear up to 17 pounds of stuck food and feces from your colon. Thus, they could only mask some of the symptoms. Taking these products was like putting a Band-Aid on a gushing wound.

How long will this offer be available?

It will be available for only a few days at this rock-bottom price… and only as long as we can keep it in stock.

Keep in mind that we only source the highest-quality ingredients not found on store shelves anywhere…

And Viscera‑3® is selling fast.

Once we run out, it can take us 3 to 6 months or more to create another batch.

Best to secure your order of Viscera‑3® now while supplies last.

Leave behind the embarrassment and pain of gas, bloating & constipation while also protecting your long-term gut health. It could not be easier or faster to stop the bloating, gas & constipation with Medical Doctor formulated Viscera-3®!

Experience it yourself
footer-guarantee

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

† Results may vary between different users due to differences in individual exercise history, genetics, age, sex, personal motivation and other factors and are in no way guaranteed. The website’s content is not a substitute for direct, personal, professional medical care and diagnosis. The products mentioned on this website should not be used without clearance from your physician or health care provider. The information contained within is not intended to provide specific physical or mental health advice or any other advice whatsoever. Please consult a physician before beginning any new supplements. Please see our full legal disclaimer for more information on typical results, risks, endorsements, and our full testimonials disclaimer: Disclaimer for typical results, testimonials, endorsements, and risks.

Please note that the information we provide is not intended to replace consultation with a qualified medical professional. We encourage you to inform your physician of changes you make to your lifestyle and discuss these with him or her. For questions or concerns about any medical conditions you may have, please contact your doctor.

Statements on this website have not been evaluated by the Food and Drug Administration. Products are not intended to diagnose, treat, cure or prevent any disease. If you are pregnant, nursing, taking medication, or have a medical condition, consult your physician before using our products.

The website's content and the product for sale is based upon the author's opinion and is provided solely on an "AS IS" and "AS AVAILABLE" basis. You should do your own research and confirm the information with other sources when searching for information regarding health issues and always review the information carefully with your professional health care provider before using any of the protocols presented on this website and/or the product sold here.

Media logos are not used to signify an endorsement but instead represent that SANESolution founder has appeared, written for, or been featured in those news and media outlets. A full list of media appearances and video examples can be found on our and press & media page. Dr. Olesiak studied at HMS.

Nothing on this page or related pages has been approved or endorsed by any institutions or persons depicted herein unless stated otherwise. Persons and events are shown to illustrate concepts, not to suggest affiliation nor endorsement.

**Please read the Store FAQ here for all terms and conditions.

Page Citations

  1. Lewandowski K, Kaniewska M, Karłowicz K, Rosołowski M, Rydzewska G. The effectiveness of microencapsulated sodium butyrate at reducing symptoms in patients with irritable bowel syndrome. Gastroenterology Review/Przegląd Gastroenterologiczny. 2022;17(1):28-34. doi:10.5114/pg.2021.112681.
  2. Pituch A, Walkowiak J, Banaszkiewicz A. Butyric acid in functional constipation. Prz Gastroenterol. 2013;8(5):295-8. doi: 10.5114/pg.2013.38731. Epub 2013 Oct 28. PMID: 24868272; PMCID: PMC4027827.
  3. Pietrzak A, Banasiewicz T. Applicability of sodium butyrate preparations from a surgeon’s and gastroenterologist’s perspective. Pol Przegl Chir. (2024);96(2):68-73. https://doi.org/10.5604/01.3001.0054.4152.
  4. Mori H, Tack J, Suzuki H. Magnesium Oxide in Constipation. Nutrients. 2021 Jan 28;13(2):421. doi: 10.3390/nu13020421. PMID: 33525523; PMCID: PMC7911806.
  5. Aniebo Umoh E, Obembe AO, Ikpi DE, Ekpenyong Eniang-Esien O, Okon Asuquo J, Effiom-Ekaha OO. Effect of chronic administration of magnesium supplement (magnesium glycinate) on male albino wistar rats' intestinal (Ileum) motility, body weight changes, food and water intake. Heliyon. 2023 Aug 9;9(8):e19042. doi: 10.1016/j.heliyon.2023.e19042. PMID: 37636381; PMCID: PMC10448020.
  6. Del Chierico F, Trapani V, Petito V, Reddel S, Pietropaolo G, Graziani C, Masi L, Gasbarrini A, Putignani L, Scaldaferri F, Wolf FI. Dietary Magnesium Alleviates Experimental Murine Colitis through Modulation of Gut Microbiota. Nutrients. 2021 Nov 23;13(12):4188. doi: 10.3390/nu13124188. PMID: 34959740; PMCID: PMC8707433.
  7. Wang H, Xue Y, Zhang H, Huang Y, Yang G, Du M, Zhu MJ. Dietary grape seed extract ameliorates symptoms of inflammatory bowel disease in IL10-deficient mice. Mol Nutr Food Res. 2013 Dec;57(12):2253-7. doi: 10.1002/mnfr.201300146. Epub 2013 Aug 21. PMID: 23963706; PMCID: PMC3976669.
  8. Nallathambi R, Poulev A, Zuk JB, Raskin I. Proanthocyanidin-Rich Grape Seed Extract Reduces Inflammation and Oxidative Stress and Restores Tight Junction Barrier Function in Caco-2 Colon Cells. Nutrients. 2020 Jun 1;12(6):1623. doi: 10.3390/nu12061623. PMID: 32492806; PMCID: PMC7352846.
  9. Wang X, Qi Y, Zheng H. Dietary Polyphenol, Gut Microbiota, and Health Benefits. Antioxidants (Basel). 2022 Jun 20;11(6):1212. doi: 10.3390/antiox11061212. PMID: 35740109; PMCID: PMC9220293.
  10. Elisa Colombo, Enrico Sangiovanni, Mario Dell'Agli, "A Review on the Anti-Inflammatory Activity of Pomegranate in the Gastrointestinal Tract", Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 247145, 11 pages, 2013. https://doi.org/10.1155/2013/247145
  11. Stockton A, Al-Dujaili EAS. Effect of Pomegranate Extract Consumption on Satiety Parameters in Healthy Volunteers: A Preliminary Randomized Study. Foods. 2022 Aug 31;11(17):2639. doi: 10.3390/foods11172639. PMID: 36076824; PMCID: PMC9455635.
  12. Anton SD, Morrison CD, Cefalu WT, Martin CK, Coulon S, Geiselman P, Han H, White CL, Williamson DA. Effects of chromium picolinate on food intake and satiety. Diabetes Technol Ther. 2008 Oct;10(5):405-12. doi: 10.1089/dia.2007.0292. PMID: 18715218; PMCID: PMC2753428.

Video Citations

  1. Department of Chemistry and Chemical Biology, Harvard University. Mohit S. Verma, Michael J. Fink, Gabriel L. Salmon. A Common Mechanism Links Activities of Butyrate in the Colon. ACS Chem. Biol. 2018, 13, 1291−1298
  2. JOHNS HOPKINS UNIVERSITY. GOPALAN SAMPATHKUMAR, ; KEVIN YAREMA. Hybrid molecule causes cancer cells to self-destruct. PUBLIC RELEASE: 3-JAN-2007.
  3. https://www.who.int/en/news-room/fact-sheets/detail/the-top-10-causes-of-death
  4. Rios-Covian, D, Ruas-Madiedo P, Margolles A, Gueimonde M, de Los Reyes-Gavilan CG, and Salazar N. Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health. Front Microbiol 7: 185, 2016.
  5. Novogrodsky,A., Dvir,A., Ravid,A., Shkolnik,T., Stenzel,K. H., Rubin,A. L, and Zaizov, R. Effect of polar organic compounds on leukemic cells. Butyrate-induced partial remission of acute myelogenous leukemia in a child. Cancer (Phila.), 51: 9—14, 1983.
  6. Kim HJ1, Leeds P, Chuang DM. The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain. J Neurochem. 2009 Aug;110(4):1226-40. doi: 10.1111/j.1471-4159.2009.06212.x. Epub 2009 Jun 15.
  7. Tao Yang and Jasenka Zubcevic. Gut–Brain Axis in Regulation of Blood Pressure. Front Physiol. 2017; 8: 845.
  8. Andoh A, Bamba T, Sasaki M. Physiological and anti-inflammatory roles of dietary fiber and butyrate in intestinal functions. JPEN J Parenter Enteral Nutr. 1999 Sep-Oct;23(5 Suppl):S70-3.
  9. Tao Yang and Jasenka Zubcevic. Gut–Brain Axis in Regulation of Blood Pressure. Front Physiol. 2017; 8: 845.
  10. Whelton S. P., Hyre A. D., Pedersen B., Yi Y., Whelton P. K., He J. (2005). Effect of dietary fiber intake on blood pressure: a meta-analysis of randomized, controlled clinical trials. J. Hypertens. 23, 475–481.
  11. Gao Z1, Yin J, Zhang J, Ward RE. Butyrate improves IS sensitivity and increases energy expenditure in mice. Diabetes. 2009 Jul;58(7):1509-17. doi: 10.2337/db08-1637. Epub 2009 Apr 14.
  12. Lin, HV, Frassetto A, Kowalik EJ, Jr., Nawrocki AR, Lu MM, Kosinski JR, Hubert JA, Szeto D, Yao X, Forrest G, and Marsh DJ. Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms. PLoS One 7: e35240, 2012.
  13. Heimann, E, Nyman M, and Degerman E. Propionic acid and butyric acid inhibit lipolysis and de novo lipogenesis and increase IS-stimulated glucose uptake in primary rat adipocytes. Adipocyte 4: 81-88, 2015.
  14. Lin, HV, Frassetto A, Kowalik EJ, Jr., Nawrocki AR, Lu MM, Kosinski JR, Hubert JA, Szeto D, Yao X, Forrest G, and Marsh DJ. Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms. PLoS One 7: e35240, 2012.
  15. Gao Z., Yin J., Zhang J., Ward R. E., Martin R. J., Lefevre M., et al. . (2009). Butyrate improves IS sensitivity and increases energy expenditure in mice. Diabetes 58, 1509–1517. 10.2337/db08-1637
  16. Zaleski, A, Banaszkiewicz A, and Walkowiak J. Butyric acid in irritable bowel syndrome. Prz Gastroenterol 8: 350-353, 2013.
  17. Banasiewicz T, Kaczmarek E, Maik J, and al. e. Quality of life and the clinical symptoms at the patients with irritable bowel syndrome treated complementary with protected sodium butyrate. Gastroenterol Prakt 5: 45-53, 2011.
  18. Velazquez, OC, Lederer HM, and Rombeau JL. Butyrate and the colonocyte. Production, absorption, metabolism, and therapeutic implications. Adv Exp Med Biol 427: 123-134, 1997.
  19. Messaoudi M, Lalonde R, Violle N, Javelot H. Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. Br J Nutr. 2011 Mar;105(5):755-64.
  20. Rao AV, Bested AC, Beaulne TM, Katzman MA. A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome. Gut Pathog. 2009 Mar 19;1(1):6.
  21. Mishiro, T, Kusunoki R, Otani A, Ansary MM, Tongu M, Harashima N, Yamada T, Sato S, Amano Y, Itoh K, Ishihara S, and Kinoshita Y. Butyric acid attenuates intestinal inflammation in murine DSS-induced colitis model via milk fat globule-EGF factor 8. Lab Invest 93: 834-843, 2013.
  22. Rabbani, GH, Albert MJ, Hamidur Rahman AS, Moyenul Isalm M, Nasirul Islam KM, and Alam K. Short-chain fatty acids improve clinical, pathologic, and microbiologic features of experimental shigellosis. J Infect Dis 179: 390-397, 1999.
  23. Kelly Cushing, David M Alvarado, Matthew A Ciorba. Butyrate and Mucosal Inflammation: New Scientific Evidence Supports Clinical Observation. Clin Transl Gastroenterol. 2015 Aug; 6(8): e108.
  24. Robert W Li. CongJun Li. Butyrate induces profound changes in gene expression related to multiple signal pathways in bovine kidney epithelial cells. BMC Genomics. 2006; 7: 234.
  25. Atweh GF1, Sutton M, Nassif I, Boosalis V. Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease. Blood. 1999 Mar 15;93(6):1790-7.
  26. Alvaro A1, Solà R, Rosales R. Gene expression analysis of a human enterocyte cell line reveals downregulation of cholesterol biosynthesis in response to short-chain fatty acids. IUBMB Life. 2008 Nov;60(11):757-64.
  27. Gao Z1, Yin J, Zhang J. Butyrate improves IS sensitivity and increases energy expenditure in mice. Diabetes. 2009 Jul;58(7):1509-17.
  28. Kim HJ1, Leeds P, Chuang DM. The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain. J Neurochem. 2009 Aug;110(4):1226-40.
  29. Tao Yang and Jasenka Zubcevic. Gut–Brain Axis in Regulation of Blood Pressure. Front Physiol. 2017; 8: 845.
  30. Mohit S. Verma, Michael J. Fink, Gabriel L. Salmon. A Common Mechanism Links Activities of Butyrate in the Colon. : ACS Chem. Biol. 2018, 13, 1291−1298
  31. Andrea Michielan, Renata D'Incà. Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis, Clinical Evaluation, and Therapy of Leaky Gut. Mediators Inflamm. 2015; 2015: 628157.
  32. Zaleski, A, Banaszkiewicz A, and Walkowiak J. Butyric acid in irritable bowel syndrome. Prz Gastroenterol 8: 350-353, 2013.
  33. Zaleski, A, Banaszkiewicz A, and Walkowiak J. Butyric acid in irritable bowel syndrome. Prz Gastroenterol 8: 350-353, 2013.
  34. Rios-Covian, D, Ruas-Madiedo P, Margolles A, Gueimonde M, de Los Reyes-Gavilan CG, and Salazar N. Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health. Front Microbiol 7: 185, 2016.
  35. Andoh A, Bamba T, Sasaki M. Physiological and anti-inflammatory roles of dietary fiber and butyrate in intestinal functions. JPEN J Parenter Enteral Nutr. 1999 Sep-Oct;23(5 Suppl):S70-3.
  36. Bach Knudsen KE, Lærke HN, Hedemann MS. Impact of Diet-Modulated Butyrate Production on Intestinal Barrier Function and Inflammation. Nutrients. 2018 Oct 13;10(10).
  37. De Preter V, Arijs I, Windey K, Vanhove W. Impaired butyrate oxidation in ulcerative colitis is due to decreased butyrate uptake and a defect in the oxidation pathway. Inflamm Bowel Dis. 2012 Jun;18(6):1127-36.
  38. Hallert C, Björck I, Nyman M. Increasing fecal butyrate in ulcerative colitis patients by diet: controlled pilot study. Inflamm Bowel Dis. 2003 Mar;9(2):116-21.
  39. Lin, HV, Frassetto A, Kowalik EJ, Jr., Nawrocki AR, Lu MM, Kosinski JR, Hubert JA, Szeto D, Yao X, Forrest G, and Marsh DJ. Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms. PLoS One 7: e35240, 2012.
  40. Yimin Jia Jian Hong Huifang Li. Butyrate stimulates adipose lipolysis and mitochondrial oxidative phosphorylation through histone hyperacetylation‐associated β3‐adrenergic receptor activation in high‐fat diet‐induced obese mice. Experimental Physiology, 28 December 2016.
  41. Byrne, CS, Chambers ES, Morrison DJ, and Frost G. The role of short chain fatty acids in appetite regulation and energy homeostasis. Int J Obes (Lond) 39: 1331-1338, 2015.
  42. Bourassa, MW, Alim I, Bultman SJ, and Ratan RR. Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health? Neurosci Lett 625: 56-63, 2016.
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