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Fast-Acting 550 mg TriButyrate Formula
Formulated by a medical doctor
Quick Bladder Relief
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Discover the freedom and confidence when you leave behind urgent bathroom trips, nighttime wake-ups, & bladder leaks

 

 

How can this new doctor-formulated TriButyrate breakthrough support bladder freedom & calm urgency so quickly?

Simple: It all starts with the patented power of TriButyrate... What is it?

Corebiome
550 mg TriButyrate Supports Bladder Freedom & Calms Urgency
Medical-Grade
TriButyrate: Corebiome® (550mg)

  • Supports The Gut-Bladder Axis With Patented TriButyrate Technology: By delivering butyrate directly to the lower gut — up to 11-times more effectively than probiotics — TriButyrate supports the signaling pathways that connect gut health to bladder function, helping calm overactive urgency signals.1

  • Supports Pelvic Floor Structure From The Inside: Emerging research indicates that postbiotic metabolites like butyrate may promote collagen and elastin expression in pelvic floor tissue — the physical support structure that holds your bladder in place and helps prevent leaks.2

  • Potent Tool For Long-Term Bladder Health: TriButyrate strengthens the gut lining, supports healthy bladder wall conditions, and helps restore the gut-bladder balance. This means your bladder confidence will get better and better the longer you take it.3

White powder
Nature's Fast, Safe, and Gentle Bladder & Muscle Support
Medical-Grade
Magnesium Blend + Oxide & Glycinate (110mg)

  • Supports Bladder Muscle Relaxation: Magnesium plays a critical role in smooth muscle function throughout the body, including the bladder. Research suggests that adequate magnesium levels may help relax the detrusor muscle, reducing the involuntary contractions that cause urgency.4

  • Calms Nerve Signaling: Magnesium glycinate is well-known for its calming effects on the nervous system. By supporting healthy nerve function, it may help quiet the overactive signals between gut and bladder that trigger the false "gotta go" feeling.5

  • Supports Overall Pelvic Health: Beyond its effects on bladder muscle tone and nerve signaling, magnesium plays a pivotal role in muscle and tissue integrity throughout the pelvic region, supporting the structures that keep your bladder functioning properly.6

Grapes
Support Bladder Wall Health, Fight Inflammation, And Strengthen The Gut-Bladder Connection
Medical-Grade
Grape Seed Extract (95% Proanthocyanidins)

  • Supports Healthy Bladder Wall Conditions: The anti-inflammatory properties of grape seed extract may help reduce the low-grade irritation that can settle on the bladder wall and trigger false urgency signals. Its proanthocyanidins support the body's natural defenses against bladder irritants.7

  • Strengthens The Gut-Bladder Barrier: Grape seed extract supports intestinal barrier integrity, which is critical for preventing the disrupted signals that travel from a compromised gut to the bladder. By strengthening the gut lining, it helps keep the gut-bladder axis functioning properly.8

  • Balances Gut Microbiota For Bladder Support: Grape seed extract promotes the growth of beneficial gut bacteria — including butyrate-producing species that research has linked to healthier bladder function. Its polyphenols act like prebiotics, supporting the microbial balance that influences bladder sensitivity.9

Pomegranate
Gut-Protective Belly-Soothing Catalysts
Medical-Grade
Synergistic Medical-Grade Nutrients That Super-Charge The Formula

  • Reduce Waist Size & Fight Gut Inflammation With Pomegranate Extract(40% Ellagic acids): Pomegranate is known as the miracle “forever fruit”. Recent studies have also revealed it as a powerful anti-aging gut health secret with potent anti-inflammatory properties, especially in the gut10. Research shows that it may help curb appetite and reduce body fat. 11

  • Chromium Picolinate To Feel Fuller and Reduce Appetite: Chromium is an essential mineral that can help in maintaining gut health and shrinking the belly. Chromium picolinate can make you feel more full and reduce cravings and appetite.12

How can this new doctor-formulated TriButyrate breakthrough support bladder freedom & calm urgency so quickly?

Simple: It all starts with the patented power of TriButyrate... What is it?

Corebiome
550 mg TriButyrate Supports Bladder Freedom & Calms Urgency
Medical-Grade
TriButyrate: Corebiome® (550mg)

  • Supports The Gut-Bladder Axis With Patented TriButyrate Technology: By delivering butyrate directly to the lower gut — up to 11-times more effectively than probiotics — TriButyrate supports the signaling pathways that connect gut health to bladder function, helping calm overactive urgency signals.1

  • Supports Pelvic Floor Structure From The Inside: Emerging research indicates that postbiotic metabolites like butyrate may promote collagen and elastin expression in pelvic floor tissue — the physical support structure that holds your bladder in place and helps prevent leaks.2

  • Potent Tool For Long-Term Bladder Health: TriButyrate strengthens the gut lining, supports healthy bladder wall conditions, and helps restore the gut-bladder balance. This means your bladder confidence will get better and better the longer you take it.3

White powder
Nature's Fast, Safe, and Gentle Bladder & Muscle Support
Medical-Grade
Magnesium Blend + Oxide & Glycinate (110mg)

  • Supports Bladder Muscle Relaxation: Magnesium plays a critical role in smooth muscle function throughout the body, including the bladder. Research suggests that adequate magnesium levels may help relax the detrusor muscle, reducing the involuntary contractions that cause urgency.4

  • Calms Nerve Signaling: Magnesium glycinate is well-known for its calming effects on the nervous system. By supporting healthy nerve function, it may help quiet the overactive signals between gut and bladder that trigger the false "gotta go" feeling.5

  • Supports Overall Pelvic Health: Beyond its effects on bladder muscle tone and nerve signaling, magnesium plays a pivotal role in muscle and tissue integrity throughout the pelvic region, supporting the structures that keep your bladder functioning properly.6

Grapes
Support Bladder Wall Health, Fight Inflammation, And Strengthen The Gut-Bladder Connection
Medical-Grade
Grape Seed Extract (95% Proanthocyanidins)

  • Supports Healthy Bladder Wall Conditions: The anti-inflammatory properties of grape seed extract may help reduce the low-grade irritation that can settle on the bladder wall and trigger false urgency signals. Its proanthocyanidins support the body's natural defenses against bladder irritants.7

  • Strengthens The Gut-Bladder Barrier: Grape seed extract supports intestinal barrier integrity, which is critical for preventing the disrupted signals that travel from a compromised gut to the bladder. By strengthening the gut lining, it helps keep the gut-bladder axis functioning properly.8

  • Balances Gut Microbiota For Bladder Support: Grape seed extract promotes the growth of beneficial gut bacteria — including butyrate-producing species that research has linked to healthier bladder function. Its polyphenols act like prebiotics, supporting the microbial balance that influences bladder sensitivity.9

Pomegranate
Gut-Protective Belly-Soothing Catalysts
Medical-Grade
Synergistic Medical-Grade Nutrients That Super-Charge The Formula

  • Reduce Waist Size & Fight Gut Inflammation With Pomegranate Extract(40% Ellagic acids): Pomegranate is known as the miracle “forever fruit”. Recent studies have also revealed it as a powerful anti-aging gut health secret with potent anti-inflammatory properties, especially in the gut10. Research shows that it may help curb appetite and reduce body fat. 11

  • Chromium Picolinate To Feel Fuller and Reduce Appetite: Chromium is an essential mineral that can help in maintaining gut health and shrinking the belly. Chromium picolinate can make you feel more full and reduce cravings and appetite.12

Quickly Support Bladder Freedom & Calm Urgency With Medical-Grade TriButyrate

Fewer Urgent Bathroom Trips In As Little As 2 Weeks

By supporting the gut-bladder axis, Viscera-3 helps calm the overactive signals that send you rushing to the bathroom — so you can go on your schedule, not your bladder's.

Support Pelvic Floor Strength From The Inside

Emerging research suggests postbiotics like tributyrin promote collagen and elastin production in pelvic floor tissue — the support structure that holds your bladder in place and helps prevent leaks.

Sleep Through The Night Without Wake-Ups

Supports calmer bladder signaling so you can enjoy uninterrupted sleep — no more 2 AM, 3 AM, and 4 AM trips to the bathroom that leave you exhausted every morning.

Calm Overactive Urgency Signals Naturally

When gut health is compromised, the nervous system pathways shared between gut and bladder can transmit overactive "gotta go" signals. Viscera-3 helps restore gut balance to calm those signals naturally — without prescription side effects.

Support Healthy Bladder Wall Conditions

Postbiotic metabolites like tributyrin may help your body maintain a healthy bladder wall environment by supporting natural defenses against irritants that can trigger false urgency.

Reclaim Your Confidence & Freedom

Stop planning your life around bathrooms. Enjoy dinners, movies, road trips, and everyday moments without the constant anxiety of "where's the nearest restroom?" holding you back.

"Viscera-3® is the most effective TriButyrate supplement for bladder support and urgency relief I've ever seen or used. Its patented POST-biotic technology targets the gut-bladder axis, supporting the structural, neurological, and inflammatory pathways that influence bladder function."Dr. Matthew Olesiak M.D., Ivy League Trained Doctor & Chief Medical Officer at SANEMD

Dr. Matthew Olesiak M.D., Ivy League Trained Doctor & Chief Medical Officer at SANEMD

Clinical and real-world results you can trust

Powerful results from clinical studies and real-world users:
  • Independent, 3rd-party studies
  • Randomized controlled trials
  • Published in Nature Microbiology

Worby CJ, Schreiber HL 4th, Straub TJ, et al. Longitudinal multi-omics analyses link gut microbiome dysbiosis with recurrent urinary tract infections in women. Nature Microbiology. 2022;7(5):630-639. doi:10.1038/s41564-022-01107-x

76%
Got Constipation Relief Within 3 Days
82%
Noticed Fewer Urgent Trips Within Two Weeks
88%
Got Better Results Than With Pumpkin Seed or Cranberry Supplements

Real people. Real results.

Scientific studies are great. But to prove our bladder support and urgency relief ingredients work for real people, we talk to our customers every day and are so happy with how quickly they feel better!

Number of Bladder and Urgency Issues

44
Week 1
36
Week 2
33
Week 3
31
Week 4
24
Week 5
18
Week 6

Total number of bladder and urgency issues reported from the Viscera-3® community.

Week 1

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Since taking it, I am noticing fewer urgent trips to the bathroom, I am sleeping better and I feel more confident going out! Gail M.

While I've just started using Viscera-3, I'm already noticing I can sit through a movie without rushing to the restroom! It's a perfect fit for me. Steven B.

I had to deal with constant urgency before taking Viscera-3. Within a couple of weeks, the "gotta go" feeling calmed down. It works and without any side effects. Lacey V.

I have always had problems with frequent bathroom trips and nighttime wake-ups and now the urgency is so much better and I'm sleeping through the night. I just feel so much more free! April L.

Viscera-3 has worked great at reducing my bladder urgency. I love that it works without the dry mouth and dizziness I had with prescription medications in the past. Tina S.

Week 2

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Viscera-3 has definitely helped me with my bladder urgency issues; I need it and wouldn't be without it. Janine C.

I was going to the bathroom 15+ times a day and waking up 3-4 times a night. Now I'm down to 7-8 trips and sleeping so much better! It works and I don't have any side effects! Catherine W.

It has helped me with all of my bladder issues and is gentle on my system. Unlike other products that I have tried, including pumpkin seed and cranberry supplements, it does exactly what it says it will do; it works! Narissa M.

Viscera-3 has done a great job of calming my urgency and reducing those embarrassing leaks. I'm finally able to go out to dinner and enjoy road trips without mapping every restroom along the way. It has given me my confidence back. Patricia W.

I have done more in the last three weeks than I have in years. It doesn't seem possible, but within two weeks of taking Viscera-3, I went to a concert and sat through the whole show without a single panicked trip to the bathroom. I cried happy tears on the way home. Lisa H.

Week 3

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After about 3 weeks of taking it, I am back to living my life without bathroom anxiety. I went on a 4-hour road trip last weekend without a single urgent stop. I have also noticed an incredible improvement in my sleep from not waking up multiple times a night. Jennifer H.

Viscera-3 does exactly what it is advertised to do. Before taking it, I constantly suffered from urgency, nighttime wake-ups, and embarrassing leaks. I am now going to the bathroom on a normal schedule and have even started exercising again without worry. Stan C.

Viscera-3 has made a huge difference in my bladder health. I tried pumpkin seed and cranberry supplements but they didn't help with the constant urgency and "gotta go" feeling. I now feel so much more in control and can enjoy outings without planning around restrooms. It works! Pamela R.

Viscera-3 is the only thing that I have tried that works. I only just started taking it 3 weeks ago but the urgency has calmed down significantly and I'm waking up far less at night. Terry M.

Week 4

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Because of Viscera-3, I no longer have the constant urgency and anxiety that I have dealt with for years. Before that, I tried everything including AZO and cranberry supplements but was still rushing to the bathroom constantly. Lisa A.

After dealing with embarrassing bladder leaks for some time, I was happy to find something that actually worked and has no side effects. Thanks to Viscera-3, I no longer dread sneezing or laughing; I will absolutely keep buying it. Harmony S.

Viscera-3 has worked very well for me. I was taking pumpkin seed extract but I was still running to the bathroom 12+ times a day. Now everything has calmed down and I can sit through a meeting or a meal without excusing myself! Valentin B.

I have already begun to feel like my old self again! It's so rewarding to go out to dinner with friends without the constant worry about where the restroom is. I finally feel free. Dottie F.

Week 5

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I decided to try Viscera-3 because nothing else was working for my bladder urgency, and I'm sure glad I did. I went from 14 bathroom trips a day to about 7! It sure works and I highly recommend it. Edmund G.

It's been so long since I have slept through the night like I do now. Before taking Viscera-3, I was up 3-4 times every night and exhausted every morning. Now I am able to enjoy full nights of rest and have energy during the day again. Brian G.

I can finally lead a normal life since taking Viscera-3. Before taking it, I avoided going out because I was terrified of not making it to a bathroom in time. Now I go to restaurants, movies, and even took a weekend trip with my family. It's the only product that has ever worked for me. Nancy T.

I noticed a difference within the first couple of weeks and it continues to reliably help with my bladder urgency. It's a product that I need and would not be without. Katrina B.

Week 6

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Now, my bathroom trips are normal, and I no longer have that constant "gotta go" feeling. I love that I have not had to deal with urgency or nighttime wake-ups over the last month! Angela T.

After so many years dealing with bladder urgency, Viscera-3 has been my life saver. I am now going on outings that I avoided for years and am feeling so much more like myself again. Maria R.

I am so happy to have discovered Viscera-3 for my bladder health. Now I wouldn't be without it. I have already noticed that my confidence is back; I feel like I have my freedom again! Brenda B.

I now have a normal bathroom schedule without the panic and rushing. It also gives you NO SIDE EFFECTS like the prescription medications I have tried. It allows you to live your life without planning every minute around the nearest restroom. I will never be without it!!! Judy L.

Experience it yourself

Shared stories, shared relief.

Safe and Effective Bladder Support & Urgency Relief

No Harmful Side Effects, Just Natural Relief

Viscera-3 is all-natural, avoiding the dry mouth, constipation, blurred vision, and cognitive concerns common with prescription bladder medications like oxybutynin and tolterodine. It's safe for ongoing use, allowing you to support bladder health without worrying about harmful long-term effects.

Targets the Root Cause and Is Safe for Long-Term Use

Unlike prescription medications that only mask urgency signals and come with significant side effects, Viscera-3 offers lasting support and is gentle on your body. It targets the gut-bladder axis — the upstream connection that influences bladder sensitivity — with natural ingredients backed by emerging research.

Uses Only the Highest-Quality, 100% Safe Ingredients

As all of our families use Viscera-3, we commit to pharmaceutical-grade, non-GMO ingredients. We adhere to GMP standards and conduct purity testing throughout the manufacturing process to support your bladder health and peace of mind.

SANE:MD Viscera-3 Pill

SANE:MD Viscera-3®

Targets the gut-bladder axis — the root cause of bladder oversensitivity

Scientifically validated natural ingredients

No side effects ever

Noticeable results in as little as 2 weeks!

Conventional Medication Pill

Conventional Medications

Only masks the urgency signals

Temporary solution with significant side effects

Dry mouth, constipation, blurred vision, dizziness

Growing concerns about long-term cognitive health

You are not alone. Feel the support
from our community...

More reviews by folks like you

4.6
Based on 979 reviews
5
 
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3
 
65
2
 
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1
 
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93% would recommend this product

Happy Viscera-3 customer
Happy Viscera-3 customer
Happy Viscera-3 customer
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Happy Viscera-3 customer

Tanya S.

  Verified Buyer

Viscera-3 Bottle

Reviewing

Viscera-3® Bladder Freedom Formula

I recommend this product

Age
55 - 64
Health concern
Constant urgency and bathroom anxiety
Months Taken
1 Month
Benefits
Found relief in 2 weeks
Viscera-3 Bottle

Reviewing

Viscera-3® Bladder Freedom Formula

1 days ago

After only 2 weeks, I experienced relief!

After ten years of dealing with bladder urgency issues, and trying several products including AZO and cranberry supplements, I was hopeful that Viscera-3 would help with my constant bathroom trips and nighttime wake-ups. My mother, who also suffers from overactive bladder, complained constantly of urgency and embarrassing leaks. I decided that if it worked for me, it could be an option for her.

I was happily surprised that after only 2 weeks, I experienced relief! My urgency has calmed down and I no longer plan my entire day around finding the nearest restroom.

For anyone thinking about trying Viscera-3, try it and give it a chance to work; even though I found relief in 2 weeks, that may not be typical so give it time.

Thank you SANEMD for making a product at a reasonable price that actually works!

Jean S.

  Verified Buyer

Viscera-3 Bottle

Reviewing

Viscera-3® Bladder Freedom Formula

I recommend this product

Age
65+
Health concern
Frequent urgency and nighttime wake-ups
Months Taken
2 Months
Benefits
Much less urgency, fewer bathroom trips and better sleep
Viscera-3 Bottle

Reviewing

Viscera-3® Bladder Freedom Formula

1 days ago

Viscera-3 Is Highly Recommended From Our House!

I decided to try Viscera-3 for several reasons. I was having trouble with constant bladder urgency and nighttime wake-ups, and my daughter was experiencing frequent embarrassing leaks and anxiety about going out.

I also knew, from experience, that SANE SOLUTIONS was a reliable firm to buy from! We have both been taking Viscera-3 for several months now and are very happy with the results.

It didn't work immediately. It took a couple of weeks for the Viscera-3 to support our gut-bladder connection. But now our bathroom trips are normal and predictable. We're both sleeping through the night and our urgency has calmed down significantly. It's so nice not to have to worry about rushing to the bathroom or mapping out every restroom before leaving the house.

Jim D.

  Verified Buyer

Viscera-3 Bottle

Reviewing

Viscera-3® Bladder Freedom Formula

I recommend this product

Age
65+
Health concern
Bladder urgency and frequency
Months Taken
Less than a month
Benefits
Fewer bathroom trips, better confidence
Viscera-3 Bottle

Reviewing

Viscera-3® Bladder Freedom Formula

3 days ago

Fewer bathroom trips without prescription side effects!

My wife and I dealt with bladder urgency for a long time. Now, after taking Viscera-3 for several months, we both feel better and are experiencing far fewer urgent bathroom trips, compared to other products we have tried including pumpkin seed and cranberry supplements. And we are no longer dealing with the dry mouth and dizziness from prescription medications so we feel so much better overall! My advice to anyone with bladder urgency is to take Viscera-3 every day.

Marie T.

  Verified Buyer

Viscera-3 Bottle

Reviewing

Viscera-3® Bladder Freedom Formula

I recommend this product

Age
55 - 64
Health concern
Constant urgency and nighttime wake-ups
Months Taken
3 Months
Benefits
Urgency calmed, sleeping through the night, more confidence
Viscera-3 Bottle

Reviewing

Viscera-3® Bladder Freedom Formula

3 days ago

No more urgency and nighttime wake-ups!

I decided to try Viscera-3 after dealing with constant bladder urgency and waking up 3-4 times every night. Not only did the urgency calm down and I started sleeping through the night, but I found my energy and confidence also increased. Give it a couple of weeks and you will notice the change.

Melyssa M.

  Verified Buyer

Viscera-3 Bottle

Reviewing

Viscera-3® Bladder Freedom Formula

I recommend this product

Age
65+
Health concern
Embarrassing bladder leaks and urgency
Months Taken
3 Months
Benefits
No more leaks, confident going out again
Viscera-3 Bottle

Reviewing

Viscera-3® Bladder Freedom Formula

4 days ago

Amazing Product!

After dealing with embarrassing bladder leaks and urgency for years, I struggled with constant bathroom anxiety almost every day. I tried a variety of pumpkin seed supplements and even prescription medications but nothing worked without terrible side effects, and I was leery of trying Viscera-3. But after having done so, it has changed my life. I'm no longer living in fear of leaks and I have confidently returned to social activities I had given up. It has worked miraculously for me; thank you! I will be ordering more.

Deborah B.

  Verified Buyer

Viscera-3 Bottle

Reviewing

Viscera-3® Bladder Freedom Formula

I recommend this product

Age
65+
Health concern
Bladder urgency for decades
Months Taken
1 Month
Benefits
Bladder is calm every day, feel a new sense of freedom
Viscera-3 Bottle

Reviewing

Viscera-3® Bladder Freedom Formula

4 days ago

Bladder Freedom!

I've had bladder urgency problems for decades and used both cranberry and pumpkin seed supplements with so-so results. I could never predict when the urgency would strike and always had to know where the nearest restroom was. Viscera-3 was a game-changer for me. I can go out and enjoy life again worry-free! Not only is my bladder calm every day, but I also feel a new sense of freedom and confidence.

Lilia P.

  Verified Buyer

Viscera-3 Bottle

Reviewing

Viscera-3® Bladder Freedom Formula

I recommend this product

Age
55 - 64
Health concern
Constant urgency and bathroom anxiety
Months Taken
2 Months
Benefits
No urgency or bathroom anxiety, finally feel normal
Viscera-3 Bottle

Reviewing

Viscera-3® Bladder Freedom Formula

6 days ago

I Love The Way It Makes Me Feel!

Before discovering Viscera-3, I always felt anxious about being too far from a bathroom. I love the way I feel now; I have no urgency or bathroom anxiety and finally feel normal. I highly recommend it because it works.

Jette S.

  Verified Buyer

Viscera-3 Bottle

Reviewing

Viscera-3® Bladder Freedom Formula

I recommend this product

Age
65+
Health concern
Severe bladder urgency and leaks
Months Taken
3 Months
Benefits
No more urgency or embarrassing leaks
Viscera-3 Bottle

Reviewing

Viscera-3® Bladder Freedom Formula

7 days ago

No More Urgency Or Leaks

After trying several different products including AZO and cranberry supplements, I was pleasantly surprised to finally find something that helped my bladder urgency. Before finding Viscera-3, I experienced severe urgency and embarrassing leaks on a regular basis. I wouldn't be without it now and highly recommend it because it works!

Jessie S.

  Verified Buyer

Viscera-3 Bottle

Reviewing

Viscera-3® Bladder Freedom Formula

I recommend this product

Age
55 - 64
Health concern
Urgency, frequency, and nighttime wake-ups
Months Taken
2 Months
Benefits
Calm bladder, sleeping through the night
Viscera-3 Bottle

Reviewing

Viscera-3® Bladder Freedom Formula

2 days ago

This product is amazing and has worked miracles!

I suffered from urgency, frequency, and nighttime wake-ups due to pelvic floor issues. Then I discovered Viscera-3 and for the first time in years, I now consistently sleep through the night and go to the bathroom on a normal schedule. This product is amazing and has worked miracles with my bladder confidence. I will never be without it.

Susan M.

  Verified Buyer

Viscera-3 Bottle

Reviewing

Viscera-3® Bladder Freedom Formula

I recommend this product

Age
65+
Health concern
Bladder never felt fully empty, constant urgency
Months Taken
1 Month
Benefits
Urgency calmed within weeks
Viscera-3 Bottle

Reviewing

Viscera-3® Bladder Freedom Formula

7 days ago

Actually, honest to God, works!

I'm the most skeptical person in the world, and I never write reviews because I don't believe them. This is my first & probably my last. I have tried pumpkin seed and cranberry supplements for 5 years; I read about Viscera-3 but was skeptical. My bathroom trips were frequent and unpredictable, and my bladder never felt fully empty, always having that constant urgency feeling. Within weeks after taking Viscera-3, I was pleasantly surprised by how calm and predictable my bladder became. The urgency was gone. I started with 1-bottle to try. Then 3 and now I'm purchasing 6 because I don't ever want to run out! It's that good!

Show More

See all reviews

All your questions answered

Can Viscera-3® really help my bladder?

Yes — and here's the science behind it. The gut-bladder axis is a recognized and active area of medical research. Multiple peer-reviewed studies published in 2024-2025 indicate that gut health influences bladder function through nervous system signaling, immune pathways, and structural tissue support.

Viscera-3® contains tributyrin — a postbiotic metabolite that supports this connection by providing the beneficial compounds that modulate these pathways. It's not a replacement for medical treatment — it's a nutritional approach that supports your body's own systems.

Over 300,000 people already use Viscera-3® for gut health. Many report improvements in bladder function as an unexpected additional benefit. The emerging research from 2024-2025 may explain why.

How is Viscera-3® different from AZO Bladder Control?

AZO uses pumpkin seed extract to support bladder muscle tone locally — directly at the bladder. Viscera-3® takes a fundamentally different approach by supporting the gut-bladder axis — the signaling pathways that influence how sensitive your bladder is in the first place.

Think of it this way: AZO works on the bladder itself. Viscera-3® works on what's telling the bladder to overreact.

For some women, the local approach is enough. But for the many women who've tried pumpkin seed supplements without sufficient results, the gut-bladder approach that Viscera-3® provides may address what was missing.

How is Viscera-3® different from cranberry supplements?

Cranberry supplements target bacteria in the urinary tract — they're designed to help prevent urinary tract infections. If your bladder issues are caused by recurring UTIs, cranberry may help.

But if your issues are urgency, frequency, and nighttime trips without infection, cranberry isn't addressing the right mechanism. It was never designed for overactive bladder.

Viscera-3® targets the gut-bladder connection — the upstream signals that influence bladder sensitivity regardless of infection. It's a completely different approach for a different problem.

I thought Viscera-3® was for gut health?

It is. And that's exactly why it may support bladder function too.

Your gut and bladder are connected through the same nervous system pathways, immune signals, and structural tissue. Supporting gut health with a targeted postbiotic like the tributyrin in Viscera-3® means supporting the upstream signals that affect how your bladder behaves.

Over 300,000 people use Viscera-3® for gut health — many report improvements in bladder function as an unexpected additional benefit. The emerging research from 2024-2025 may explain why so many customers have experienced this.

How long until I notice a difference with Viscera-3®?

Most users report noticing fewer urgent bathroom trips within 2-4 weeks. More significant improvement in overall frequency and nighttime wake-ups typically develops by 6-8 weeks. Full benefits of postbiotic support generally establish by 90 days.

For some people, the benefits may not appear gradually but rather all at once — once the tributyrin in Viscera-3® has reached the levels necessary to support the gut-bladder connection.

The good news? Our 365-day money-back guarantee gives you more than enough time to evaluate honestly — unlike the 30-day guarantees most competitors offer.

Will I still need to do Kegels?

Kegels strengthen pelvic floor muscles through physical exercise — working from the outside. Viscera-3® supports the same structures from the inside through gut-derived signals that promote collagen and elastin in pelvic floor tissue.

They work through different mechanisms and complement each other beautifully. We recommend continuing Kegels alongside Viscera-3® for the best possible results.

Is Viscera-3® safe with my medications?

Tributyrin is a naturally occurring fatty acid found in everyday foods like butter and dairy. There are no known drug interactions, and over 300,000 people currently use Viscera-3® without issue.

As with any supplement, we recommend consulting your healthcare provider if you take prescription medications — particularly bladder-specific prescriptions like oxybutynin, tolterodine, or mirabegron.

I'm embarrassed to talk to my doctor about this. Is Viscera-3® enough?

You're not alone — most women wait an average of six years before discussing bladder issues with anyone. The embarrassment is real, and we understand.

Viscera-3® is a reasonable first step, especially with our 365-day guarantee that lets you evaluate the results privately and risk-free. No awkward conversations needed.

That said, if your symptoms are severe, worsening rapidly, or accompanied by pain, blood in urine, or fever, please see a healthcare provider. For the millions of women managing everyday urgency, frequency, and occasional leaks, a bladder support supplement like Viscera-3® is a sensible starting point.

How many bottles of Viscera-3® should I order?

Research on postbiotic benefits suggests a 60-90 day timeline for the full gut-bladder connection to establish — so we recommend at least a 3-month supply. That said, results improve the longer Viscera-3® is taken, and once you start feeling the freedom, you'll never want to stop.

Do yourself a favor and order the 6-bottle bundle. It saves you the most money (up to 72% off!), and you won't have to worry about running out during the critical window when the tributyrin is building up in your system.

Remember, Viscera-3® contains the highest-grade nutrients and the patented, superior form of TRIButyrate, and we produce it in small batches for maximum freshness and effectiveness. They sell out often, so stock up today.

Of course, if you decide the product is not for you, you can always return the unused portion for a refund — we offer a 1-year satisfaction guarantee** so you're always safe.

What if I get it and it's just not for me?

You're going to love Viscera-3®, but even if you don't, you're covered! Every customer is protected by a full ONE-YEAR, no questions asked, FULL MONEY BACK GUARANTEE.**

That's 365 days — the longest guarantee in the bladder support category by far. Most competitors offer just 30 days, which isn't even long enough for a natural supplement to show its full effect. We give you a full year because we're that confident in what Viscera-3® can do for your bladder freedom.

You can feel confident taking advantage of the HUGE savings when you order multiple bottles today.

What are the nutrients and amounts in SANE Viscera-3®?

Have a look for yourself:

Viscera-3 supplement label

Where is Viscera-3® manufactured?

Viscera-3® is doctor-formulated, third-party tested, and proudly manufactured, packed, and shipped in the USA.

Is Viscera-3® non-GMO and gluten-free?

Yes! None of our products contain GMO foods or gluten.

How long will this offer be available?

It will be available for only a few days at this rock-bottom price… and only as long as we can keep it in stock.

Keep in mind that we only source the highest-quality ingredients not found on store shelves anywhere… and Viscera-3® is selling fast.

Once we run out, it can take us 3 to 6 months or more to create another batch.

Best to secure your order of Viscera-3® now while supplies last.

Leave behind the embarrassment of urgent bathroom trips, nighttime wake-ups & bladder leaks while also protecting your long-term bladder health. It could not be easier or faster to support bladder freedom & confidence with Medical Doctor formulated Viscera-3®!

Experience it yourself
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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

† Results may vary between different users due to differences in individual exercise history, genetics, age, sex, personal motivation and other factors and are in no way guaranteed. The website’s content is not a substitute for direct, personal, professional medical care and diagnosis. The products mentioned on this website should not be used without clearance from your physician or health care provider. The information contained within is not intended to provide specific physical or mental health advice or any other advice whatsoever. Please consult a physician before beginning any new supplements. Please see our full legal disclaimer for more information on typical results, risks, endorsements, and our full testimonials disclaimer: Disclaimer for typical results, testimonials, endorsements, and risks.

Please note that the information we provide is not intended to replace consultation with a qualified medical professional. We encourage you to inform your physician of changes you make to your lifestyle and discuss these with him or her. For questions or concerns about any medical conditions you may have, please contact your doctor.

Statements on this website have not been evaluated by the Food and Drug Administration. Products are not intended to diagnose, treat, cure or prevent any disease. If you are pregnant, nursing, taking medication, or have a medical condition, consult your physician before using our products.

The website's content and the product for sale is based upon the author's opinion and is provided solely on an "AS IS" and "AS AVAILABLE" basis. You should do your own research and confirm the information with other sources when searching for information regarding health issues and always review the information carefully with your professional health care provider before using any of the protocols presented on this website and/or the product sold here.

Media logos are not used to signify an endorsement but instead represent that SANESolution founder has appeared, written for, or been featured in those news and media outlets. A full list of media appearances and video examples can be found on our and press & media page. Dr. Olesiak studied at HMS.

Nothing on this page or related pages has been approved or endorsed by any institutions or persons depicted herein unless stated otherwise. Persons and events are shown to illustrate concepts, not to suggest affiliation nor endorsement.

**Please read the Store FAQ here for all terms and conditions.

Page Citations

  1. Worby CJ, Schreiber HL 4th, Straub TJ, et al. Longitudinal multi-omics analyses link gut microbiome dysbiosis with recurrent urinary tract infections in women. Nature Microbiology. 2022;7(5):630-639. doi:10.1038/s41564-022-01107-x
  2. Okamoto T, Hatakeyama S, Imai A, et al. The influence of gut microbiome on progression of overactive bladder symptoms: a community-based 3-year longitudinal study. International Urogynecology Journal. 2022;33:1039-1048. PMID: 34714460
  3. Wang W, Zhu Q, Xia Y, et al. Tributyrin alleviates gut microbiota dysbiosis to repair intestinal damage in antibiotic-treated mice. PLoS ONE. 2023;18(7):e0289364. doi:10.1371/journal.pone.0289364
  4. Saraç Sivrikoz T, Kılıç M. The effect of magnesium on overactive bladder. Urologia Internationalis. 2020;104(11-12):873-878. doi:10.1159/000510182
  5. Boyle NB, Lawton C, Dye L. The effects of magnesium supplementation on subjective anxiety and stress — a systematic review. Nutrients. 2017;9(5):429. doi:10.3390/nu9050429
  6. de Baaij JH, Hoenderop JG, Bindels RJ. Magnesium in man: implications for health and disease. Physiological Reviews. 2015;95(1):1-46. doi:10.1152/physrev.00012.2014
  7. Wang H, Xue Y, Zhang H, et al. Dietary grape seed extract ameliorates symptoms of inflammatory bowel disease in IL10-deficient mice. Molecular Nutrition & Food Research. 2013;57(12):2253-2257. doi:10.1002/mnfr.201300146/li>
  8. Gil-Cardoso K, Ginés I, Pinent M, Ardévol A, Blay M, Terra X. Effects of flavonoids on intestinal inflammation, barrier integrity and changes in gut microbiota during diet-induced obesity. Nutritional Research Reviews. 2016;29(2):234-248. doi:10.1017/S0954422416000159
  9. Liu W, Zhao S, Wang J, et al. Grape seed proanthocyanidin extract ameliorates inflammation and adiposity by modulating gut microbiota in high-fat diet mice. Molecular Nutrition & Food Research. 2017;61(9):1601082. doi:10.1002/mnfr.201601082
  10. Elisa Colombo, Enrico Sangiovanni, Mario Dell'Agli, "A Review on the Anti-Inflammatory Activity of Pomegranate in the Gastrointestinal Tract", Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 247145, 11 pages, 2013. https://doi.org/10.1155/2013/247145
  11. Stockton A, Al-Dujaili EAS. Effect of Pomegranate Extract Consumption on Satiety Parameters in Healthy Volunteers: A Preliminary Randomized Study. Foods. 2022 Aug 31;11(17):2639. doi: 10.3390/foods11172639. PMID: 36076824; PMCID: PMC9455635.
  12. Anton SD, Morrison CD, Cefalu WT, Martin CK, Coulon S, Geiselman P, Han H, White CL, Williamson DA. Effects of chromium picolinate on food intake and satiety. Diabetes Technol Ther. 2008 Oct;10(5):405-12. doi: 10.1089/dia.2007.0292. PMID: 18715218; PMCID: PMC2753428.

Video Citations

  1. Department of Chemistry and Chemical Biology, Harvard University. Mohit S. Verma, Michael J. Fink, Gabriel L. Salmon. A Common Mechanism Links Activities of Butyrate in the Colon. ACS Chem. Biol. 2018, 13, 1291−1298
  2. JOHNS HOPKINS UNIVERSITY. GOPALAN SAMPATHKUMAR, ; KEVIN YAREMA. Hybrid molecule causes cancer cells to self-destruct. PUBLIC RELEASE: 3-JAN-2007.
  3. https://www.who.int/en/news-room/fact-sheets/detail/the-top-10-causes-of-death
  4. Rios-Covian, D, Ruas-Madiedo P, Margolles A, Gueimonde M, de Los Reyes-Gavilan CG, and Salazar N. Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health. Front Microbiol 7: 185, 2016.
  5. Novogrodsky,A., Dvir,A., Ravid,A., Shkolnik,T., Stenzel,K. H., Rubin,A. L, and Zaizov, R. Effect of polar organic compounds on leukemic cells. Butyrate-induced partial remission of acute myelogenous leukemia in a child. Cancer (Phila.), 51: 9—14, 1983.
  6. Kim HJ1, Leeds P, Chuang DM. The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain. J Neurochem. 2009 Aug;110(4):1226-40. doi: 10.1111/j.1471-4159.2009.06212.x. Epub 2009 Jun 15.
  7. Tao Yang and Jasenka Zubcevic. Gut–Brain Axis in Regulation of Blood Pressure. Front Physiol. 2017; 8: 845.
  8. Andoh A, Bamba T, Sasaki M. Physiological and anti-inflammatory roles of dietary fiber and butyrate in intestinal functions. JPEN J Parenter Enteral Nutr. 1999 Sep-Oct;23(5 Suppl):S70-3.
  9. Tao Yang and Jasenka Zubcevic. Gut–Brain Axis in Regulation of Blood Pressure. Front Physiol. 2017; 8: 845.
  10. Whelton S. P., Hyre A. D., Pedersen B., Yi Y., Whelton P. K., He J. (2005). Effect of dietary fiber intake on blood pressure: a meta-analysis of randomized, controlled clinical trials. J. Hypertens. 23, 475–481.
  11. Gao Z1, Yin J, Zhang J, Ward RE. Butyrate improves IS sensitivity and increases energy expenditure in mice. Diabetes. 2009 Jul;58(7):1509-17. doi: 10.2337/db08-1637. Epub 2009 Apr 14.
  12. Lin, HV, Frassetto A, Kowalik EJ, Jr., Nawrocki AR, Lu MM, Kosinski JR, Hubert JA, Szeto D, Yao X, Forrest G, and Marsh DJ. Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms. PLoS One 7: e35240, 2012.
  13. Heimann, E, Nyman M, and Degerman E. Propionic acid and butyric acid inhibit lipolysis and de novo lipogenesis and increase IS-stimulated glucose uptake in primary rat adipocytes. Adipocyte 4: 81-88, 2015.
  14. Lin, HV, Frassetto A, Kowalik EJ, Jr., Nawrocki AR, Lu MM, Kosinski JR, Hubert JA, Szeto D, Yao X, Forrest G, and Marsh DJ. Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms. PLoS One 7: e35240, 2012.
  15. Gao Z., Yin J., Zhang J., Ward R. E., Martin R. J., Lefevre M., et al. . (2009). Butyrate improves IS sensitivity and increases energy expenditure in mice. Diabetes 58, 1509–1517. 10.2337/db08-1637
  16. Zaleski, A, Banaszkiewicz A, and Walkowiak J. Butyric acid in irritable bowel syndrome. Prz Gastroenterol 8: 350-353, 2013.
  17. Banasiewicz T, Kaczmarek E, Maik J, and al. e. Quality of life and the clinical symptoms at the patients with irritable bowel syndrome treated complementary with protected sodium butyrate. Gastroenterol Prakt 5: 45-53, 2011.
  18. Velazquez, OC, Lederer HM, and Rombeau JL. Butyrate and the colonocyte. Production, absorption, metabolism, and therapeutic implications. Adv Exp Med Biol 427: 123-134, 1997.
  19. Messaoudi M, Lalonde R, Violle N, Javelot H. Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. Br J Nutr. 2011 Mar;105(5):755-64.
  20. Rao AV, Bested AC, Beaulne TM, Katzman MA. A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome. Gut Pathog. 2009 Mar 19;1(1):6.
  21. Mishiro, T, Kusunoki R, Otani A, Ansary MM, Tongu M, Harashima N, Yamada T, Sato S, Amano Y, Itoh K, Ishihara S, and Kinoshita Y. Butyric acid attenuates intestinal inflammation in murine DSS-induced colitis model via milk fat globule-EGF factor 8. Lab Invest 93: 834-843, 2013.
  22. Rabbani, GH, Albert MJ, Hamidur Rahman AS, Moyenul Isalm M, Nasirul Islam KM, and Alam K. Short-chain fatty acids improve clinical, pathologic, and microbiologic features of experimental shigellosis. J Infect Dis 179: 390-397, 1999.
  23. Kelly Cushing, David M Alvarado, Matthew A Ciorba. Butyrate and Mucosal Inflammation: New Scientific Evidence Supports Clinical Observation. Clin Transl Gastroenterol. 2015 Aug; 6(8): e108.
  24. Robert W Li. CongJun Li. Butyrate induces profound changes in gene expression related to multiple signal pathways in bovine kidney epithelial cells. BMC Genomics. 2006; 7: 234.
  25. Atweh GF1, Sutton M, Nassif I, Boosalis V. Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease. Blood. 1999 Mar 15;93(6):1790-7.
  26. Alvaro A1, Solà R, Rosales R. Gene expression analysis of a human enterocyte cell line reveals downregulation of cholesterol biosynthesis in response to short-chain fatty acids. IUBMB Life. 2008 Nov;60(11):757-64.
  27. Gao Z1, Yin J, Zhang J. Butyrate improves IS sensitivity and increases energy expenditure in mice. Diabetes. 2009 Jul;58(7):1509-17.
  28. Kim HJ1, Leeds P, Chuang DM. The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain. J Neurochem. 2009 Aug;110(4):1226-40.
  29. Tao Yang and Jasenka Zubcevic. Gut–Brain Axis in Regulation of Blood Pressure. Front Physiol. 2017; 8: 845.
  30. Mohit S. Verma, Michael J. Fink, Gabriel L. Salmon. A Common Mechanism Links Activities of Butyrate in the Colon. : ACS Chem. Biol. 2018, 13, 1291−1298
  31. Andrea Michielan, Renata D'Incà. Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis, Clinical Evaluation, and Therapy of Leaky Gut. Mediators Inflamm. 2015; 2015: 628157.
  32. Zaleski, A, Banaszkiewicz A, and Walkowiak J. Butyric acid in irritable bowel syndrome. Prz Gastroenterol 8: 350-353, 2013.
  33. Zaleski, A, Banaszkiewicz A, and Walkowiak J. Butyric acid in irritable bowel syndrome. Prz Gastroenterol 8: 350-353, 2013.
  34. Rios-Covian, D, Ruas-Madiedo P, Margolles A, Gueimonde M, de Los Reyes-Gavilan CG, and Salazar N. Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health. Front Microbiol 7: 185, 2016.
  35. Andoh A, Bamba T, Sasaki M. Physiological and anti-inflammatory roles of dietary fiber and butyrate in intestinal functions. JPEN J Parenter Enteral Nutr. 1999 Sep-Oct;23(5 Suppl):S70-3.
  36. Bach Knudsen KE, Lærke HN, Hedemann MS. Impact of Diet-Modulated Butyrate Production on Intestinal Barrier Function and Inflammation. Nutrients. 2018 Oct 13;10(10).
  37. De Preter V, Arijs I, Windey K, Vanhove W. Impaired butyrate oxidation in ulcerative colitis is due to decreased butyrate uptake and a defect in the oxidation pathway. Inflamm Bowel Dis. 2012 Jun;18(6):1127-36.
  38. Hallert C, Björck I, Nyman M. Increasing fecal butyrate in ulcerative colitis patients by diet: controlled pilot study. Inflamm Bowel Dis. 2003 Mar;9(2):116-21.
  39. Lin, HV, Frassetto A, Kowalik EJ, Jr., Nawrocki AR, Lu MM, Kosinski JR, Hubert JA, Szeto D, Yao X, Forrest G, and Marsh DJ. Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms. PLoS One 7: e35240, 2012.
  40. Yimin Jia Jian Hong Huifang Li. Butyrate stimulates adipose lipolysis and mitochondrial oxidative phosphorylation through histone hyperacetylation‐associated β3‐adrenergic receptor activation in high‐fat diet‐induced obese mice. Experimental Physiology, 28 December 2016.
  41. Byrne, CS, Chambers ES, Morrison DJ, and Frost G. The role of short chain fatty acids in appetite regulation and energy homeostasis. Int J Obes (Lond) 39: 1331-1338, 2015.
  42. Bourassa, MW, Alim I, Bultman SJ, and Ratan RR. Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health? Neurosci Lett 625: 56-63, 2016.
  43. Rao AV, Bested AC, Beaulne TM, Katzman MA. A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome. Gut Pathog. 2009 Mar 19;1(1):6.
  44. Rao AV, Bested AC, Beaulne TM, Katzman MA. A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome. Gut Pathog. 2009 Mar 19;1(1):6.
  45. Zi-Xing Chen and Theodore IL Breitman. Tributyrin: A Prodrug of Butyric Acid for Potential Clinical Application in Differentiation Therapy. CANCER RESEARCH 54, 3494-3499, July 1, 1994.
  46. American Osteopathic Association. Up to 50 percent of US population is magnesium deficient. February 26, 2018.
  47. Harvard T.H. Chan School Of Public Health. Magnesium - Nutrition Source.
  48. Harvard Health Publishing. What you should know about magnesium.
  49. Ismail, A. A., & Ismail, N. A. (2016). Magnesium: A Mineral Essential for Health Yet Generally Underestimated or Even Ignored. Journal of Nutrition & Food Sciences, 6(4). doi:10.4172/2155-9600.1000523
  50. Simental-Mendía LE, Rodríguez-Morán M, Guerrero-Romero F. Oral magnesium supplementation decreases C-reactive protein levels in subjects with prediabetes and hypomagnesemia: a clinical randomized double-blind placebo-controlled trial. Arch Med Res. 2014 May;45(4):325-30.
  51. Nicholas E. Diamant, M.D. Pathophysiology of gastroesophageal reflux disease. GI Motility online (2006) doi:10.1038/gimo21
  52. Murakami, K., Sasaki, S., Okubo, H., Takahashi, Y., Hosoi, Y., & Itabashi, M. (2006). Association between dietary fiber, water and magnesium intake and functional constipation among young Japanese women. European Journal of Clinical Nutrition,61(5), 616-622. doi:10.1038/sj.ejcn.1602573
  53. Hruby, A., Meigs, J. B., Odonnell, C. J., Jacques, P. F., & Mckeown, N. M. (2013). Higher Magnesium Intake Reduces Risk of Impaired Glucose and IS Metabolism and Progression From Prediabetes to Diabetes in Middle-Aged Americans. Diabetes Care,37(2), 419-427. doi:10.2337/dc13-1397
  54. Boyle, N.B., Lawton, C., & Dye, L. (2017). The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review. Nutrients,9(5), 429. doi:10.3390/nu9050429
  55. Harvard T.H. Chan School of Public Health. The nutrition source: Magnesium.
  56. American Osteopathic Association. Up to 50 percent of US population is magnesium deficient. February 26, 2018.
  57. Anton SD, Morrison CD, Cefalu WT. Effects of chromium picolinate on food intake and satiety. Diabetes Technol Ther. 2008 Oct;10(5):405-12.
  58. Anderson RA1, Cheng N, Bryden NA. Elevated intakes of supplemental chromium improve glucose and IS variables in individuals with type 2 diabetes. Diabetes. 1997 Nov;46(11):1786-91.
  59. Mertz W. Interaction of chromium with IS: a progress report. Nutr Rev 1998;56:174-7.
  60. Porte Jr. D, Sherwin RS, Baron A (editors). Ellengerg & Rifkin’s Diabetes Mellitus, 6th Edition. McGraw-Hill, New York, 2003.
  61. Anton SD1, Morrison CD, Cefalu WT. Effects of chromium picolinate on food intake and satiety. Diabetes Technol Ther. 2008 Oct;10(5):405-12.
  62. McCarty MF. Longevity effect of chromium picolinate--'rejuvenation' of hypothalamic function? Med Hypotheses. 1994 Oct;43(4):253-65.
  63. Mertz W. Interaction of chromium with IS: a progress report. Nutr Rev 1998;56:174-7.
  64. Schwarz K, Mertz W. Chromium(III) and the glucose tolerance factor. Arch Biochem Biophys 1959;85:292-5.
  65. Haili Zhang, MM,a Shuang Liu, MM,b Lan Li, BD,b Shisong Liu, BD. The impact of grape seed extract treatment on blood pressure changes
    A meta-analysis of 16 randomized controlled trials. Medicine (Baltimore). 2016 Aug; 95(33): e4247.
  66. Park E, Edirisinghe I, Choy YY, Waterhouse A, Burton-Freeman B. Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomised, double-blinded, two-arm, parallel, placebo-controlled trial. Br J Nutr. 2016 Jan 28;115(2):226-38.
  67. Sano A, Uchida R, Saito M. Beneficial effects of grape seed extract on malondialdehyde-modified LDL. J Nutr Sci Vitaminol (Tokyo). 2007 Apr;53(2):174-82.
  68. Safaei N, Babaei H, Azarfarin R, Jodati AR. Comparative effect of grape seed extract (Vitis vinifera) and ascorbic acid in oxidative stress induced by on-pump coronary artery bypass surgery. Ann Card Anaesth. 2017 Jan-Mar;20(1):45-51.
  69. Calapai G, Bonina F, Bonina A. A Randomized, Double-Blinded, Clinical Trial on Effects of a Vitis vinifera Extract on Cognitive Function in Healthy Older Adults. Front Pharmacol. 2017 Oct 31;8:776.
  70. Sarkaki A, Rafieirad M, Hossini SE. Improvement in Memory and Brain Long-term Potentiation Deficits Due to Permanent Hypoperfusion/Ischemia by Grape Seed Extract in Rats. Iran J Basic Med Sci. 2013 Sep;16(9):1004-10.
  71. Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther. 1998 Oct;23(5):385-9.
  72. Ryu D, Mouchiroud L, Andreux PA, Katsyuba E. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nat Med. 2016 Aug;22(8):879-88. doi: 10.1038/nm.4132. Epub 2016 Jul 11.
  73. Sedigheh Asgary Amirhossein Sahebkar Mohammad Reza Afshani. Clinical Evaluation of Blood Pressure Lowering, Endothelial Function Improving, Hypolipidemic and Anti‐Inflammatory Effects of Pomegranate Juice in Hypertensive Subjects. Phytotherapy Research. Volume 28, Issue2. February 2014.
    Pages 193-199.
  74. Mirmiran P, Fazeli MR, Asghari G, Shafiee A, Azizi F. Effect of pomegranate seed oil on hyperlipidaemic subjects: a double-blind placebo-controlled clinical trial. Br J Nutr. 2010 Aug;104(3):402-6. doi: 10.1017/S0007114510000504.
  75. Bookheimer SY, Renner BA, Ekstrom A. Pomegranate juice augments memory and FMRI activity in middle-aged and older adults with mild memory complaints. Evid Based Complement Alternat Med. 2013;2013:946298.
  76. Susan A. Ropacki, Sapna M. Patel, Richard E. Hartman. Pomegranate Supplementation Protects against Memory Dysfunction after Heart Surgery: A Pilot Study. Evid Based Complement Alternat Med. 2013; 2013: 932401.
  77. Colombo E, Sangiovanni E, Dell'agli M. A review on the anti-inflammatory activity of pomegranate in the gastrointestinal tract. Evid Based Complement Alternat Med. 2013;2013:247145.
  78. Gonçalves P, Martel F. Butyrate and colorectal cancer: the role of butyrate transport. Curr Drug Metab. 2013 Nov;14(9):994-1008.
  79. Rios-Covian, D, Ruas-Madiedo P, Margolles A, Gueimonde M, de Los Reyes-Gavilan CG, and Salazar N. Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health. Front Microbiol 7: 185, 2016.
  80. Gao Z., Yin J., Zhang J., Ward R. E., Martin R. J., Lefevre M., et al. . (2009). Butyrate improves IS sensitivity and increases energy expenditure in mice. Diabetes 58, 1509–1517. 10.2337/db08-1637
  81. Kim HJ1, Leeds P, Chuang DM. The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain. J Neurochem. 2009 Aug;110(4):1226-40. doi: 10.1111/j.1471-4159.2009.06212.x. Epub 2009 Jun 15.
  82. Colombo E, Sangiovanni E, Dell'agli M. A review on the anti-inflammatory activity of pomegranate in the gastrointestinal tract. Evid Based Complement Alternat Med. 2013;2013:247145.
  83. Andoh A, Bamba T, Sasaki M. Physiological and anti-inflammatory roles of dietary fiber and butyrate in intestinal functions. JPEN J Parenter Enteral Nutr. 1999 Sep-Oct;23(5 Suppl):S70-3.
  84. Tao Yang and Jasenka Zubcevic. Gut–Brain Axis in Regulation of Blood Pressure. Front Physiol. 2017; 8: 845.
  85. Whelton S. P., Hyre A. D., Pedersen B., Yi Y., Whelton P. K., He J. (2005). Effect of dietary fiber intake on blood pressure: a meta-analysis of randomized, controlled clinical trials. J. Hypertens. 23, 475–481.
  86. Gao Z1, Yin J, Zhang J, Ward RE. Butyrate improves IS sensitivity and increases energy expenditure in mice. Diabetes. 2009 Jul;58(7):1509-17. doi: 10.2337/db08-1637. Epub 2009 Apr 14.
  87. Lin, HV, Frassetto A, Kowalik EJ, Jr., Nawrocki AR, Lu MM, Kosinski JR, Hubert JA, Szeto D, Yao X, Forrest G, and Marsh DJ. Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms. PLoS One 7: e35240, 2012.
  88. Heimann, E, Nyman M, and Degerman E. Propionic acid and butyric acid inhibit lipolysis and de novo lipogenesis and increase IS-stimulated glucose uptake in primary rat adipocytes. Adipocyte 4: 81-88, 2015.
  89. Lin, HV, Frassetto A, Kowalik EJ, Jr., Nawrocki AR, Lu MM, Kosinski JR, Hubert JA, Szeto D, Yao X, Forrest G, and Marsh DJ. Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms. PLoS One 7: e35240, 2012.