Irritable Bowel Syndrome (IBS)

Research has in the past suggested probiotics may be useful in treating people with IBS. The exact mechanism for exactly how probiotics may reduce IBS symptoms is largely unknown at this time. It is speculated that the effects of probiotics on alterations in gut bacteria are involved.

What causes irritable bowel syndrome?

The causes of irritable bowel syndrome are multifactorial and may include:

Alterations in gut motility

Within the gut, there is a cyclic pattern of motility known as the major migrating complex, which consists of periodic, luminal contractions that propel intestinal contents from the stomach to the terminal ileum. Several studies in the literature have shown that patients with IBS tend to have abnormalities in these contractions.

Small-bowel bacterial overgrowth

A large study of 202 patients with IBS found that 78% showed evidence of bacterial overgrowth via breath testing. 25 of 47 patients experienced eradication of bacterial overgrowth on follow-up after treatment with antibiotics. Analysis of this subset of patients revealed that those who were successful in the eradication of bacterial overgrowth reported improvement in their IBS symptoms. (2)

Microscopic inflammation

It has been postulated that the release of certain inflammatory mediators, including interleukins and histamine, may affect nearby enteric nerves, causing alteration in gut function and sensory perception.

Visceral hypersensitivity

Visceral hypersensitivity is recognized as a candidate. VH contributes to pain associated with this syndrome.

Pathophysiology of IBS and how we view probiotics

First, disordered physiological processes associated with disease or injury or pathophysiology of IBS will be discussed. Then, we will review evidence for using probiotics in treating irritable bowel syndrome (IBS). Finally, an alternative to probiotics in the form of postbiotics (specifically, Tributyrate) will be presented.

IBS is the most common GI condition, which accounts for approximately 30 percent of all referrals to GI doctors! The kicker? The actual process remains uncertain!

Despite multiple investigations, data have been conflicting, and no abnormality has been found to be specific to this disorder. (1)

Probiotics and the evidence in IBS

According to a recent publication analysis by the Canadian Society of Intestinal Research, multiple studies on probiotics in patients with IBS still show that the results are mixed. This is not surprising, the society concludes, as different probiotics are like different drugs. And they are correct!

Here is the summary:

1. Lactobacillus plantarum 299V; overall symptoms improved for patients in one of two studies where pain and gas  improved in one of two studies. There was no significant improvement in constipation.
2. Lactobacillus acidophilus SDC 2012 and 2013 strains; improvement in pain and straining, but no change in frequency.
3. Lactobacillus acidophilus LB strain; all 18 patients and found improvement in “overall symptoms” after 6 weeks.
4. Lactobacillus acidophilus species in combination with other probiotics; probiotic mix was significantly more effective in improving overall IBS symptoms, pain, and gas but not bloating.
5. Lactobacillus rhamnosis strains (GG and Lc705) plus Propionibacterium freudenreichii (subspecies shermanii JS) plus a strain of Bifidobacterium; One study showed an improvement in gas or quality of life. Both studies showed an improvement in IBS symptoms and pain. There was no change in constipation/diarrhea.
6. Bifidobacterium infantis 35624; No quality of life improved with one ‘overall symptoms improved’ and one of two studies reported positive effects on bowel movement frequency.
7. Bifidobacterium animalis DN 173010 (Activia® yogurt); overall results were negative however the study should remain inconclusive.
8. Escherichia coli DSM 17252; improvement in overall symptoms and pain. One study showed an improvement in bloating.
9. Bacillus coagulans GBI-30 6086; First, after treatment in IBS patients first we note that abdominal pain scores were improved in all 7 weeks in the treatment group next, bloating improved with treatment in all 7 weeks where finally, none of 7 weeks with placebo.

Conclusion and what can be done about IBS now?

This blog post covers what is reported to date. The report is for a total of nine probiotic organisms. The nine probiotic species spans 14 studies. On a large scale, research is required over a longer period of time.

There are several probiotic supplements on the market today. But research clearly shows, Viscera-3 is superior to any other postbiotic or probiotics brand and may help you tackle the symptoms of IBS.

With Viscera-3, this superior form of TRIbutyrate is time-released directly into your lower colon (the only place it can provide all the above life-changing benefits).

It is three times more potent than the weak short-chain fatty acids created by fiber alone. Along with TRIButyrate, Viscera-3 contains the SLIMGut Earth Minerals Matrix™ and the SLIMGut Garden Blend™.

Together, their powerful multi-factor effect on gut health leads to less gas, constipation, bloating, and of course, faster weight loss! No increasing fiber intake is required.

This patented nutrient is the fastest, easiest, and most effective way to poop a more normal, healthier stool and enjoy a slimmer, less bloated waist in just 48 hours!

NOTE: this does not replace the advice of your physician, whom you should always consult for specific treatment recommendations.