Postbiotics Supplements Make Prebiotic & Probiotics Obsolete
Postbiotics with the proper organic acids and bioactive compounds allow for a myriad of health benefits that replace probiotics and prebiotics. If you want to become healthier and have a vibrant healthy gut microbiome, you’ll need to take care of your gut bacteria, starting with postbiotics. When we take in fiber, it travels to our colon where it is fermented by “good bacteria” (probiotics). This bacteria through a fermentation process hen excretes postbiotics which can unleash health benefits such as:
- Improve gut health
- Leaky gut repair
- Attend to inflammation (Anti Inflammatory response)
- Boost immune response (also Anti Inflammatory)
….and so much more, as you’ll find out in this detailed gut health Postbiotics guide.
Postbiotics Supplements index:
For ease of navigation through this SANESolution Gut Health Postbiotics Supplements Guide (we go way beyond simple food sci and functional foods or suggestions), below is the table of contents.
- What Are Postbiotics?
- Postbiotics metabolic products (organic acids) And How They Help You
- How are Postbiotics Different From Prebiotics?
- Postbiotics vs Probiotics
- Postbiotics and Dietary Fiber
- Postbiotics And Gut Health
- Postbiotics and Leaky Gut
- Postbiotics and Inflammation
- Postbiotics and Immune Response
- Why Harvard Calls Butyrate the “Optimal” of Postbiotics
- Postbiotic Foods? Not From Your Diet!
- Postbiotics and Butyrate: Why TRIButyrate is the Best Way to Get Butyrate
- Postbiotics Conclusion
- Postbiotics Guide Citations and References
Postbiotics and supplements guide: The fundamentals:
In the postbiotics fundamental section, we are going to uncover the basic science behind gut microbiota and how health benefits of postbiotics relate to them. 100 trillion microorganisms, mostly bacteria, live in your gastrointestinal tract. These microorganisms, called “gut microbiota,” or gut microbiome, were once thought to control digestion, nutrient absorption, and excretion.
Now, scientists have discovered that your gut microbiota is important for your overall health and has tremendous amounts of health benefits. An imbalance of good and bad gut bacteria (dysbiosis) has been linked to many poor health benefits outcomes and medical conditions including Obesity, Diabetes, and Chronic kidney disease 1,2 Multiple studies also show that having a diverse microbiome (a variety of different strains and qualities of bacteria) is crucial to overall health.3,4 Postbiotics can help provide this diversity as well as rebalance your gut bacteria. In fact, these patented supplements can even replace your prebiotics and probiotics!
If you’re wondering what these compounds are, you’re not alone. Postbiotics is a fairly new term (“postbiotics an evolving term?” – yep!) in the microbiology field. As you’re probably more familiar with prebiotics and probiotics, we’ll start there. Probiotics / prebiotics increase the number and diversity of beneficial gut bacteria (gut microbes or microbiota). Research shows that increasing beneficial gut bacteria can support your health in many ways. Furthermore, it’s important to note that our bacteria provide benefits to the host aka us humans (they may even help us poop out fat!)
Postbiotics are “waste” metabolic products left behind from the interaction between prebiotics and probiotics. They are a result of “good” bacteria fermentation process inside your colon which provides health benefit to our immune system and so much more.
The difference between prebiotics probiotics and Postbiotics
Specifically, when you consume fiber from food, it travels to your lower intestine (colon) where it is eaten (fermentation process) by your good bacteria (probiotics). This bacteria then excretes postbiotics. Still unsure about the differences? That’s OK! You can check out Runner’s World comparison of prebiotics, probiotics, and postbiotics as well as Dr. Axe’s description of their differences at great length to get a better idea!
Though “waste” products sound like something unimportant, the benefits of postbiotics may help and be the key factor in obtaining the health benefits (or any health benefit for that matter like weight loss or setpoint weight management) promised by eating a high-fiber diet. Indeed, the different strains of beneficial bacteria are known to produce various types of post biotic metabolites to support a healthy mind and body.
Postbiotics and their metabolites (bioactive compounds)
Postbiotics contain metabolites are the compounds created from the probiotic fermentation process. More than 22,000 metabolites are identified in scientific literature.5 Each of these metabolites provide different health benefits, and the exact effects seem to depend upon the interaction between the host (you) and the metabolite. Various postbiotics metabolites have been shown to have the following potential health benefits (which have been compared to probiotics and prebiotics many times over) Anti-obesity, Anti-inflammatory, and Antioxidant properties.
Postbiotics health benefits may even extend to: Lower blood pressure, Reduce cholesterol levels, and Regulate the immune system response. In short, postbiotics may even have a direct impact on health specifically from postbiotic and host beneficial effects even though researchers have not yet discovered the exact mechanism for this effect and more clinical trials of course, are needed.6
Most-studied postbiotics metabolites
What are postbiotic metabolites that we do know? Well, along with some of their positive effects with health-regulating benefits (talk about benefits to the host!), postbiotics play a role in some of the most complex immune function pathways from cell to cell interactions and more. Here is an high level postbiotics beneficial effects and interactions.
12 Postbiotics Metabolic Products With Benefits to the Host:
B-vitamin synthesis: (biotin, cobalamin, folate, nicotinic acid, pantothenic acid, pyridoxine, riboflavin, and thiamine)7: These vitamins are essential to health and life. They play a huge role in cardiovascular health, hormones and cholesterol production, proper nerve function, energy levels, brain function, and more. Vitamin K8: Essential for proper blood clotting and bone metabolism. It also regulates blood calcium levels.
Short-chain fatty acids (SCFAs): acetic, propionic and butyrate.9: They provide important functions in your body. Specific SCFAs from postbiotics may reduce your risk of cancer, gastrointestinal disorders, cardiovascular disease, and much more.10 Glutathione 11: Postbiotics may reduce the risk of several diseases – including diabetes, cancer, and rheumatoid arthritis – by reducing oxidative stress.12 (Oxidative stress in the cells occurs when the body cannot fight off free radicals sufficiently.)
Antimicrobial peptides (AMPs) 13: Postbiotics may protect the body against dangerous pathogens. And unlike traditional antibiotics, antimicrobial peptides appear to slow pathogenic resistance to them.14 This means they can be more effective for long-term use than antibiotics. Phenyllactic acid 15: Postbiotics may and have shown antibacterial properties against various bacteria.
D-amino acids 16: Appear to have bacteria regulatory properties. Hydrogen peroxide 17: Has been shown to have antibacterial properties that may help you fight off infection.
Volatile organic compounds (VOCs) 18: Postbiotics may serve as a marker for the presence or absence of certain harmful bacteria. This can help doctors administer the proper treatment more quickly than they have been able to do in the past. Phytoestrogens: equol, enterolactone, enterodiol 19: Mimics the female hormone estrogen in the body, which can modulate the symptoms of menopause.
Urolithin A and Urolithin B 20: Like phytoestrogens, they may display behavior that mimics that of estrogen in the body. Fulvic acids: Helps carry nutrients into the cells. Thus, fulvic acids may lessen free radical damage, among other things. 21
postbiotics and prebiotics difference?
Like all live microorganisms, bacteria needs to eat to survive. Prebiotics are the food sources of beneficial colon residing bacteria. There are key differences between Postbiotics and Prebiotics, although their relationship is interdependent. (The creation of them depends upon the existence of prebiotics.) You may have stumbled across postbiotics being discussed within the functional foods field. It’s also possible that you fell upon the evolving term within the scientific association for probiotics.
Either way – you must be wondering at this point – how are probiotics postbiotics different from the effects of prebiotics on microbiota (and probiotics for that matter)? Prebiotic fiber is of a different nature than what we are talking about here, though, where our patented postbiotics products (you’ll soon learn) have quite the positive effects!
Prebiotic food contain dietary fibers that pass through the upper part of the digestive system intact because the body cannot break them down. When they get to the colon, “good” live microorganisms or bacteria ferment them. Postbiotic is a byproduct created from prebiotic fermentation.
Prebiotics are typically found in food
Leeks, Asparagus, Onions, Chicory root, Dandelion greens, and Garlic.
Why probiotics are replaced
Postbiotics vs probiotics can be a good leisure-time debate. But there’s really no comparison between the two as their health promoting and beneficial effects on the human body drastically differ. Postbiotics are created when “good” bacteria ferment dietary fiber in the colon. (Good bacteria = probiotics. Dietary fiber = prebiotics.)
Good Bacteria = Probiotics and Dietary Fiber = Prebiotics
Once considered just a waste product without value, postbiotics have actually been shown to have many health benefits that are vastly different from probiotics.
You can get gut health probiotics through your diet and food, this is reported as true and. no international scientific association or society will argue this point. Probiotic food is created from fermentation and thus contain live bacteria (live microorganisms) that can help benefit and rebalance your intestinal bacteria.
When it comes to gut health and the immune system, the beneficial effects of postbiotics may help the good cells produced by our digestive system. Postbiotics and their metabolites (waste products) include health promoting pathways that are deeply linked with our total body immunity. The biochemistry of the gut is incredibly diverse and complex from waste products to organic acids and health promoting metabolites. Having a healthy gut requires far more than taking in foods like yogurt or leafy greens as not all organic acids are created equal.
Health Promoting Probiotic-rich food:
Yogurt (for best results, check the ingredient label and make sure it includes L. acidophilus, a type of bacteria shown to be particularly beneficial to human health.)
Sauerkraut, Kefir, Tempeh, Brine-cured olives, Miso, Raw milk (from cows, goats, or sheep), Fermented pickles (Not all pickles are fermented. Pickles made with vinegar are not fermented and do NOT contain live bacteria. If you’re looking for fermented pickles, always check the label to make sure they’re fermented.)
However, research shows that many probiotic supplement brands fail to adequately protect bacteria from human digestion. Far too often, the bacteria in probiotic supplements do not reach the intestines in a usable state.22
This is also true for some of these digestive healthy supplements. For instance, doctors at Harvard Medical School call butyrate the “optimal” short-chain fatty acid and note that it “shows a higher potency” and added health benefits than other short-chain fatty acids.23
Yet, if taken in supplement form, it breaks up long before it reaches the colon. (More about this in a moment.) Of the three short-chain fatty acid postbiotics (acetate and propionate), this SCFA is the least abundant metabolite produced from probiotic fermentation. Yet, it is the major energy source for epithelial cells of the colon.24 Thus, this short chain FA is extremely important for intestine health, as well as overall health, as we’ll see in a moment.
But if you cannot get much through probiotic fermentation, what do you do?
Dietary fiber or prebiotics:
To get these SCFA’s you can, of course, load up on dietary fiber from food intake. This will perhaps slightly increase the amount of compound yielded from the fermentation process from our microbiota. Though dietary fiber and food packed with it helps create them like our novel SCFA, it’s a very inefficient process when compared to postbiotics. When you eat food with fiber, it moves through your entire digestive system until it finally gets to your colon.
Only then does your colonic microbiota biome or bacteria digest the fiber, fermenting it in your colon. (This is why you often experience painful bloating and embarrassing gas when you eat more fiber.)
You can also get this form of biotic directly from certain foods, such as butter and ghee, but the amount you’d get is even less than that created through probiotic fermentation.
You can also get this form of postbiotics directly from certain nutrition foods, such as butter and ghee, but the amount of postbiotics you’d get is even less than that created through probiotic fermentation! As you can see, the positive health benefit is difficult to obtain or be utilized by host microorganisms without supplementation! What you need is the right form of postibiotics. The best Postbiotics include a processes that skips this inefficient digestive process and goes straight to your colonic cell. There is such a postbiotics product. But before we get to that, let’s discuss some of the amazing health benefits of it.
Postbiotics positive effects on gut health
If you’re read this far, you know that these postbiotics are more than just a term within the functional medicine society. Postbiotics as nutraceuticals are great for digestive health.
How effective are postbiotics for gut-related issues? Very! Let’s start with an increasingly common gastrointestinal condition — irritable bowel syndrome.
Postbiotics and IBS
According to the International Foundation for Gastrointestinal Disorders, irritable bowel syndrome (IBS) is the “most common functional gastrointestinal (GI) disorder.”25 IBS affects as many as 45 million people in the United States.26 Symptoms of IBS range from mild to severe, and include stomach pain and/or bloating, excessive gas, and diarrhea or constipation.27 Treatment in the early stages of IBS usually focuses on relieving these symptoms with dietary modifications. Research shows that postbiotics may also help relieve these symptoms.
More on postbiotics potential in gut health:
According to a 2013 study, this SCFA can reduce the hypersensitivity of intestinal receptors, resulting in a decrease of pressure inside the intestines.28 This may help in reducing the pain and bloating of IBS. It can also ease constipation by helping the bowel muscles contract and retract properly.29 It also supports the health of the cell type lining the intestine and reduces intestinal inflammation, easing the pain and digestive symptoms of IBS.30,31,32
Although these studies focus on IBS, the results can apply to other gastrointestinal complaints. This may help keep your large intestine healthy and may help in preventing colon cancer.34 It doesn’t get much better than this for colonic and stomach health! But there’s more.
Benefits of postbiotics include leaky gut:
Like in poor gut health states with IBS, the postbiotics metabolites contain compounds that have potential applications and may help fix leaky gut, a condition that plagues so many people. Leaky gut syndrome is a condition in which your intestinal barrier becomes “leaky,” allowing toxins and other harmful substances to enter your bloodstream. How do your walls become “leaky?” It starts with your intestinal wall. You see, a layer of cells line your intestines, making up your intestinal wall.
These cells are connected by gates that are called “tight junctions”. These gates allow water and nutrients to enter your colon, while also keeping toxins and other harmful substances from escaping into your bloodstream. If these gates weaken, it causes gaps in the intestinal wall. This allows harmful substances to “leak” into your bloodstream, which can put you at risk for many health problems.
Leaky gut syndrome includes:
Irritable bowel disease, Crohn’s disease, Diabetes, Food allergies, Polycystic ovary syndrome, Anxiety, Depression, Fatigue, Headaches, and Joint pain 35 Research shows that a postbiotics metabolite, butyric acid, may help fix many aspects of leaky gut syndrome and by extension – help maintain prime gut health environments. For instance, through a few mechanisms, but mainly through its role in ATP production, butenoate has been shown to repair and enhance the barrier function of intestinal cell types.
Basically, postbiotics make sure your cells have what they need to keep the “gates” functioning perfectly.36 Studies also show that postbiotics directly influences the gastrointestinal flora, helping to balance colonic bacteria. Postbiotics may even play a beneficial role in treating gastrointestinal infections. Both are important factors in preventing or treating leaky gut.37,38
Postbiotics may help lower and have positive effects on inflammation:
Butyric acid obtained from postbiotics is one of the colonic supplements that can help with general inflammation. This is important because systemic inflammation has become a villain in medicine. Every cell can become ransacked by negative effects of an inflammatory state.
Chronic inflammation has been associated with a wide range of health conditions and diseases, including: Obesity, Heart Disease, Diabetes, Metabolic syndrome, Psoriasis, Inflammatory bowel disease, and Asthma 39 The postbiotics metabolites may help lower and have shown to help reduce or prevent inflammation. As previously mentioned, having a healthy colon is crucial.
Postbiotics and inflammatory responses:
Postbiotics can help regulate your immune response, which can reduce or eliminate systemic inflammation. Before we continue, it’s important to know that inflammation isn’t always a negative occurrence. In fact, it is a vital part of your immune response.
When the immune system detects an intruder — pathogens, toxins, and other foreign bodies — it launches an attack to kill it. One of its weapons is inflammation, which traps the intruders so that they cannot travel to other parts of the body. (This type of acute inflammation is characterized by swelling and redness at the site of the invasion/infection.)
The problem is when inflammation continues
White blood cells then move in to fight the infection and heal the injury. As the body heals, inflammation gradually recedes and then disappears. The problem arises when inflammation doesn’t go away but becomes chronic which is detrimental for gut health even if you’re physically fit. This can happen for a number of reasons, including hypersensitivity to harmless substances, or long-term, low-level exposure to toxins. Intestinal gut health or health promoting compounds like postbiotics can help. Research shows that these postbiotics can calm and quiet your immune system by down-regulating your T-cells.46
Postbiotics may help lower poor gut health environments and they can also help your intestine cells grow, helping to fill in the damaged areas so that toxic substances can’t leak into the bloodstream and trigger the immune response and resulting inflammation.47
Why Harvard Calls Butyrate “Optimal”
Harvard calls butyrate the “optimal” postbiotics primarily because of its effect on histone deacetylases (HDACs). This is crucial for, among other things, preventing cancers, especially colon cancer and keeping gut health optimal. In a 2018 Harvard study, researchers found that postbiotics (specifically butyrate) keep colonic epithelial stem cell line from rapidly multiplying, and it suppresses inflammation, which inhibits the activity of HDAC.
Indeed, researchers concluded that butyrate is the strongest inhibitor of the activity of HDACs, among the short-chain fatty acids.48 This is one of many studies that show that butyrate may defend against colon cancer. Another reason for this effect is that butyrate is the main source of energy for cells that line the colon. This is true even when glucose is present.49 And let’s not forget the study mentioned earlier in this report, the one that showed postbiotics can trigger “cell suicide” in the colon, causing cancer cells to die!
Foods Contain Postbiotics?
You’re probably wondering if you can get enough by eating specific foods like we mentioned here and still have gut health be optimal.
The answer is “no.”
Since these molecules are created through fermentation of fiber in your colon, there are few helpful foods. (There are only trace amounts of it in butter, ghee, raw milk, plant oils, and animal fats.) And even if you significantly increased your fiber intake, you still wouldn’t get a huge amount of postbiotics. Plus, you’d be left with painful and embarrassing gas, bloating, and stomach cramps from all that fiber. So, to get a healthy dose of postbiotics and butyrate as a nutrient, you’ll really need to take it in supplement form. There’s only one problem, though. By itself is a VERY stinky nutrient.
Why Postbiotics TRIButyrate is the best
Postbiotics TRIButyrate is the superior patented form of butyrate. It is hands down – the most effective and efficient way to transport butyrate to your colon. (Tributyrin is the natural form of butyrate found in butter.) After years of research, scientists have combined 3 Butyrate molecules with a glycerol molecule to create a radically more effective version of this “optimal” short-chain fatty acid.50 And that’s how TRIButyrate was created.
There are several supplements for gut health on the market today. Research clearly shows, Viscera-3 is superior to any other postbiotic brand.
With Viscera-3, this superior form of TRIbutyrate is time-released directly into your lower colon (the only place it can provide all the above life-changing gut health benefits). It is three times more potent than the weak short-chain fatty acids created by fiber alone. Along with TRIButyrate, Viscera-3 contains the SLIMGut Earth Minerals Matrix™ and the SLIMGut Garden Blend™. Together, their powerful multi-factor effect on gut health leads to less gas, constipation, bloating, and of course faster setpoint weight loss! No increasing your fiber intake required.
This patented nutrient is the fastest, easiest and most effective way to poop a more normal, healthier stool and enjoy a slimmer, less bloated waist in just 48 hours!
As you’ve seen in this report, you don’t need to waste money on foods like we listed in this guide or — prebiotics and probiotics — instead take the “gut health shortcut” to support gut health which, of course, also improves your overall health.
Now with Viscera-3 (Rights Reserved by SANE) you can save time and money by leaving behind the old 5-step process for gut health. As a reminder, when you eat fiber (prebiotics), it travels through the gastrointestinal system. When it gets to your colon, it is fermented by beneficial bacteria (probiotics). This live bacteria then excretes postbiotic metabolites — including that all-important nutrient — which Harvard doctors describe as an “optimal” short-chain fatty acid.
With SANE’s top postbiotics line, Viscera-3, you can do away with this inefficient 5-step process and transport this patented , more effective and bioavailable form of butyrate straight to your colon. It’s quick and easy — and it helps fix so many of your digestive and bathroom issues, such as gas and bloating. It works for your overall health, too.
You can locate the full list of references for this guide on our medical bibliography page that is updated frequently! SANE Rights Reserved