Butyrate Supplements

Butyrate Supplements

Sodium butyrate and butyrate supplements deriving from this compound are well-known for their immune-modulating characteristics. The systemic anti-inflammatory effects of sodium butyrate supplementation in humans have been studied. (1)

During one particular study, Butyrate supplements were found to moderately affect some cytokine responses. Additionally, it was found that Butyrate Supplements taken orally may play a role in reducing the inflammatory state of circulating monocytes in patients with Metabolic Syndrome.

Butyrate Supplements & Side Effects

The Mayo Clinic, in March of this year, reported the side effects of Sodium Phenylbutyrate (Oral Route) and categorized them by:

More Common

Less Common

Rare (2)

Sodium Phenylbutyrate, in this report, was indicated in treating urea cycle disorders as an adjunct to a proper diet. Additionally, it is indicated to aid the removal of ammonia or nitrogen from the body.

An infographic of Butyrate side effects.

Infographic Text

More Common:

  • change in the frequency of breathing
  • lack of or irregular menstruation
  • lower back, side, or stomach pain
  • mood or mental changes
  • muscle pain or twitching
  • nausea or vomiting

Less Common:

  • chills
  • fever
  • joint pain
  • sore throat
  • unusual bleeding
  • bruising


  • convulsions (seizures)
  • dizziness
  • dryness of the mouth
  • fast, slow, or irregular heart
  • increased blood pressure
  • increased thirst
  • irritability

End Infographic Text

Our Gut Biome & Best Butyrate Supplements

A large volume of research and study over the previous few years has made it abundantly clear that the microbial environment residing in the human gut plays a key part in maintaining human homeostasis. The microbial community pulls energy from our diets, supports our mucosal barriers, and even regulates immune responses. (3,4)

A singular and crucial microbial event — the production of Short Chain Fatty Acids (SCFA) within the large intestine (5) — has been found to have a hand in all of these protective functions. 

These SCFAs result from the bacterial fermentation of complex carbohydrates in the lower colon. 

Butyrate Biochemistry:

Downstream, as we continue along the biochemical pathway, the benefits of butyrate SCFA’S (Postbiotics) play an obvious role in digestive health, bowel movement regularity, microbiome support, and much more.

To get these incredibly helpful postbiotics, one can, of course, increase their intake of dietary fiber, which will minimally increase butyrate production. Though dietary fiber does indeed aid in forming postbiotics such as butyrate, the process lacks efficiency.

In addition, consuming too much fiber in an attempt to increase levels of butyrate will cause painful bloating and increased unwanted flatulence. That is why the best postbiotics are butyrate supplements and not actually a singular short-chain fatty acid!

Can These Supplements Really Help Prevent Colonic Disease?

As SCFA’s go, butyrate has been shown to play a significant role in cell differentiation – a process that aids in colonic disease prevention. Specifically, where colon cancer cells are concerned,  butyrate has been proposed to modulate proliferation, differentiation, and apoptosis. That is to say – butyrate inhibits the growth of colon cancer cells and promotes healthy colonic epithelium. This scenario has been charmingly called the “butyrate paradox”(6).

How Do These Supplements Modulate Immune Response?

Butyrate acts upon regulatory T cells to decrease TNF-alpha & IL-6 production, modulating an immune response. Additionally, this SCFA increases the levels of other anti-inflammatory immune cells, such as M2 macrophages. It also inhibits pro-inflammatory immune cells such as M1 macrophages and neutrophils. (7)

As a quick summary, insulin sensitivity suggests that butyrate is produced by resistant starch gut bacteria. The effect of butyrate is to help maintain the barrier function between digestive toxins and our blood circulation!


Postbiotic Supplements? Enter Tributyrate & Viscera-3

As a result of many years of conducting research, scientists have now combined three Butyrate molecules with a single glycerol molecule to create an incredibly more effective version of this “optimal” short-chain fatty acid, butyrate. The benefits of no longer requiring prebiotic and probiotic ingestions a few times per day are numerous and obvious.

An image of a smiling female doctor and a bottle of Viscera-3.

Until recently, fiber and probiotics were the only supplements that helped your lower colon create incredibly powerful health-promoting gut nutrients known as Short Chain Fatty Acids (SCFAs).

With Viscera-3, this superior form of TRIbutyrate is intelligently time-released directly into the lower portion of your colon – right in the region where the appropriate health benefits can occur.

Viscera-3 as a butyrate supplement is three times more potent than fiber alone. Additionally, it contains the SLIMGut Earth Minerals Matrix™ and the SLIMGut Garden Blend™.

Viscera-3, as a result, provides a tidal wave of gut health without constipation, bloating, or gas pain and tops the experience off with faster weight loss. Fiber supplements can retire from the shelves.

This patented nutrient is the fastest, easiest, and most effective way to a more normal, healthier stool while enjoying a slimmer, less bloated waist in just 48 hours!

Dumping more probiotics into an unhealthy gut is like pouring gas in an engine that does not run, it is a waste of money! Leave behind the slow 5-step process and flip on your SLIM GUT SWITCH in one step!

Butyrate Article Definitions:

Monocytes: Monocytes are a type of leukocyte or white blood cell. They are the largest type of leukocyte and can differentiate into macrophages and myeloid lineage dendritic cells.

Metabolic Syndrome: Metabolic syndrome is a cluster of conditions that occur together, increasing your risk of heart disease, stroke, and type 2 diabetes. These conditions include increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels.

Homeostasis: In biology, homeostasis is the state of steady internal, physical, and chemical conditions maintained by living systems.

Fermentation: Fermentation is a metabolic process. This process includes organic molecules (normally glucose), and they change into acids, gases, or alcohol in the absence of oxygen or any electron transport chain.

Urea Cycle Disorders: Primary urea cycle disorders (UCDs) include carbamoyl phosphate synthase (CPS) deficiency, ornithine transcarbamylase (OTC) deficiency, argininosuccinate synthetase deficiency (citrullinemia), argininosuccinate lyase deficiency (argininosuccinic aciduria), and arginase deficiency (argininemia).

Anaerobic gram-positive bacteria: Gram-positive anaerobic cocci (GPAC) are a heterogeneous group of organisms defined by their morphological appearance and their inability to grow in the presence of oxygen; most clinical isolates are identified to species in the genus Peptostreptococcus.

Human Colon Anatomy For Reference:

 A 3d image of the human body showing the colon with text labeling specific parts of it. Text is described below.


Parts of the colon text 

  • transverse colon
  • ascending colon
  • descending colon
  • sigmoid colon
  • rectum

End parts of colon text

References For Further Research & Study:

  1. Effects of oral butyrate supplementation on inflammatory potential of circulating peripheral blood mononuclear cells in healthy and obese males
    Maartje C. P. Cleophas,1,2 Jacqueline M. Ratter,1,2,3 Siroon Bekkering,1,2 Jessica Quintin,5 Kiki Schraa,1 Erik S. Stroes,4 Mihai G. Netea,1,2,6 and Leo A. B. Joostencorresponding author1,2,7
  2. Mayo Clinic: https://www.mayoclinic.org/drugs-supplements/sodium-phenylbutyrate-oral-route/side-effects/drg-20066057, March 1st, 2020
  3. D’Argenio V, Salvatore F. The role of the gut microbiome in the healthy adult status. Clin Chim Acta. 2015;451:97–102. doi: 10.1016/j.cca.2015.01.003. [PubMed] [CrossRef] [Google Scholar]
  4. Heintz-Buschart, A. & Wilmes, P. Human Gut Microbiome: Function Matters. Trends Microbiol, 10.1016/j.tim.2017.11.002 (2017).
  5. Rios-Covian D, et al. Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health. Front Microbiol. 2016;7:185. doi: 10.3389/fmicb.2016.00185. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  6. Cellular differentiation: Potential insight into butyrate paradox? Stacy H. Ryu,a Gerard E. Kaiko,a and Thaddeus S. Stappenbecka,b https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150034/
  7. Metabolic Functions of Gut Microbes Associate With Efficacy of Tumor Necrosis Factor Antagonists in Patients With Inflammatory Bowel Diseases. Gastroenterology Vol. 157 Issue 5.