Paraprobiotics: non-viable probiotics
What are paraprobiotics and what impact do they have on our health?
You may already know that postbiotics (also known as metabolites) are “waste products” or byproducts of secreted live bacteria in the gut. In the classical definition of probiotics we can conclude that they are live microorganisms and in theory, have a positive health impact on their host (us humans) if ingested in large amounts. Knowledge on the types of paraprobiotics and postbiotics is so far still limited. The paraprobiotics mechanisms of action and postbiotics in the same context, remains to be fully discovered.
So where do paraprobiotics play a role?
Probiotics have been observed to exhibit several health benefits by modulating gut microbiome; however, they are severely dulled in comparison to their potential because of their flawed design. Most probiotics never make it to the intended site of action within the colon. As such, a massive shift in focus is taking place this very moment from viable probiotic bacteria towards non-viable paraprobiotics or probiotics derived biomolecules aka postbiotics.
It can be tentatively concluded that paraprobiotics are an emerging concept in the functional foods field because they exhibit massive potential health-promoting properties much like postbiotics.
Lactobacillus, paraprobiotics, and postbiotics studies
Paraprobiotics and postbiotics are both obtained from biochemical isolation techniques where the method of isolating these “compounds” influences their health benefits. Meaning, paraprobiotics and postbiotics are influenced by their isolation methods (1)
Recent studies observed that most of the paraprobiotics are located in the bacterial cell-envelope and consist of molecules such as peptidoglycans, surface proteins, cell wall polysaccharides. Postbiotics on the other hand, include secreted proteins and peptides, bacteriocins, organic acid and some other molecules and bacterial debris. (2)
Postbiotics and paraprobiotics behave positively in some cases
Both paraprobiotics and postbiotics play a role in a wide range of positive effects on the host such as immunomodulatory, anti-tumor, barrier-preservation, and antimicrobial properties.(3) Different species of Lactobacillus have different types of postbiotics and it appears now, paraprobiotics as well.
Paraprobiotics and postbiotics health benefits?
Paraprobiotics and postbiotics derived from the infamous Lactobacillus bacteria consist of a wide range of molecules known as ‘effectors’. They are products and byproducts of the probiotic Lactobacillus and have been found to exhibit potentially powerful benefits to humans such as:
- Preservation of the epithelial barrier
- Antagonistic Role Against Pathogens
What do we do with parapriobiotics now?
As in most cases when something new is discovered, more research is required. There are still, several aspects related to paraprobiotics biochemical behavior that remains unexplored and poorly understood.
There are several supplements on the market today. Research clearly shows, Viscera-3 is superior to any other postbiotics brand. With Viscera-3, this superior form of TRIbutyrate is time-released directly into your lower colon (the only place it can provide all the above life-changing benefits).
It is three times more potent than the weak short-chain fatty acids created by fiber alone. Along with TRIButyrate, Viscera-3 contains the SLIMGut Earth Minerals Matrix™ and the SLIMGut Garden Blend™. Together, their powerful multi-factor effect on gut health leads to less gas, constipation, bloating, and of course faster setpoint weight loss! No increasing your fiber intake required.
- Barros CP, Guimaraes JT, Esmerino EA, Duarte MCKH, Silva MC, Silva R, et al. Paraprobiotics and postbiotics: concepts and potential applications in dairy products. Curr Opin Food Sci. (2020) 32:1–8. 10.1016/j.cofs.2019.12.003
- Lactobacillus plantarum possesses the capability for wall teichoic acid backbone alditol switching. Bron PA, Tomita S, van Swam II, Remus DM, Meijerink M, Wels M, Okada S, Wells JM, Kleerebezem M Microb Cell Fact. 2012 Sep 11; 11():123.
- Metabiotics: novel idea or natural development of probiotic conception.Shenderov BA Microb Ecol Health Dis. 2013; 24():